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    tel2 TTT co-chaperone complex LRR repeat subunit Tel2 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2543639, updated on 18-Sep-2024

    Summary

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    Official Symbol
    tel2
    Official Full Name
    TTT co-chaperone complex LRR repeat subunit Tel2
    Primary source
    PomBase:SPAC458.03
    Locus tag
    SPOM_SPAC458.03
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See tel2 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    1
    Sequence:
    Chromosome: I; NC_003424.3 (4734821..4737598)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene tRNA (cytosine-5-)-methyltransferase Neighboring gene mRNP complex protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene meiotic dynein intermediate light chain Dli1/Dil1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Branching the Tel2 pathway for exact fit on phosphatidylinositol 3-kinase-related kinases. Sugimoto K. Curr Genet, 2018 Oct. PMID 29470645, Free PMC Article
    2. A tel2 Mutation That Destabilizes the Tel2-Tti1-Tti2 Complex Eliminates Rad3(ATR) Kinase Signaling in the DNA Replication Checkpoint and Leads to Telomere Shortening in Fission Yeast. Xu YJ, et al. Mol Cell Biol, 2019 Oct 15. PMID 31332096, Free PMC Article
    3. Tel2 is required for activation of the Mrc1-mediated replication checkpoint. Shikata M, et al. J Biol Chem, 2007 Feb 23. PMID 17189249
    4. CK2 phospho-independent assembly of the Tel2-associated stress-signaling complexes in Schizosaccharomyces pombe. Inoue H, et al. Genes Cells, 2017 Jan. PMID 27935167
    5. The Hsp90 cochaperone TTT promotes cotranslational maturation of PIKKs prior to complex assembly. Toullec D, et al. Cell Rep, 2021 Oct 19. PMID 34686329

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Tel2 role in the telomere shortening and RAD3 signaling.
      Title: A tel2 Mutation That Destabilizes the Tel2-Tti1-Tti2 Complex Eliminates Rad3(ATR) Kinase Signaling in the DNA Replication Checkpoint and Leads to Telomere Shortening in Fission Yeast.
    2. It has become apparent in the last decade that the stability or maturation of the PIKK family members depends on a molecular chaperone called the Tel2-Tti1-Tti2 (TTT) complex
      Title: Branching the Tel2 pathway for exact fit on phosphatidylinositol 3-kinase-related kinases.
    3. the Tel2 phosphorylation by CK2 is not required for the various stress responses to which PIKKs are pivotal. Our results suggest that the Tel2-containing protein complexes are conserved among eukaryotes, but the molecular regulation of their formation has been altered during evolution.
      Title: CK2 phospho-independent assembly of the Tel2-associated stress-signaling complexes in Schizosaccharomyces pombe.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables Hsp90 protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to protein-macromolecule adaptor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables telomeric DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in 'de novo' cotranslational protein folding EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in 'de novo' cotranslational protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of TTT Hsp90 cochaperone complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol HDA PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    NOT is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    TTT co-chaperone complex LRR repeat subunit Tel2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      4734821..4737598
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001020125.3 → NP_594697.1  TTT co-chaperone complex LRR repeat subunit Tel2 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_594697.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q9P3W5
      Conserved Domains (1) summary
      pfam10193
      Location:507 → 618
      Telomere_reg-2; Telomere length regulation protein
    Nucleotide Protein
    Heading Accession and Version

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