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    pmd1 leptomycin transmembrane transporter Pmd1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2538709, updated on 18-Sep-2024

    Summary

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    Official Symbol
    pmd1
    Official Full Name
    leptomycin transmembrane transporter Pmd1
    Primary source
    PomBase:SPCC663.03
    Locus tag
    SPOM_SPCC663.03
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See pmd1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    2
    Sequence:
    Chromosome: III; NC_003421.2 (1635093..1640571)

    Chromosome III - NC_003421.2Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene wtf element Wtf14 Neighboring gene ncRNA Neighboring gene wtf element Wtf15 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene GTPAse-interacting protein Neighboring gene 60S ribosomal protein L39 Neighboring gene histone H3-H4 chaperone Asf1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003421.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A leptomycin B resistance gene of Schizosaccharomyces pombe encodes a protein similar to the mammalian P-glycoproteins. Nishi K, et al. Mol Microbiol, 1992 Mar. PMID 1349418
    2. Microarray-based target identification using drug hypersensitive fission yeast expressing ORFeome. Arita Y, et al. Mol Biosyst, 2011 May. PMID 21340088
    3. P-glycoprotein and vacuolar ATPase synergistically confer anthracycline resistance to fission yeast and human cells. Tay Z, et al. Curr Med Chem, 2014. PMID 24059229
    4. Analyzing fission yeast multidrug resistance mechanisms to develop a genetically tractable model system for chemical biology. Kawashima SA, et al. Chem Biol, 2012 Jul 27. PMID 22840777, Free PMC Article
    5. Cellular robustness conferred by genetic crosstalk underlies resistance against chemotherapeutic drug doxorubicin in fission yeast. Tay Z, et al. PLoS One, 2013. PMID 23365689, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables ABC-type xenobiotic transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase-coupled transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in xenobiotic detoxification by transmembrane export across the plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in fungal-type vacuole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    leptomycin transmembrane transporter Pmd1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003421.2 Reference assembly

      Range
      1635093..1640571
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001355925.2 → NP_001342744.1  leptomycin transmembrane transporter Pmd1 [Schizosaccharomyces pombe]

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O74513, P36619
      Conserved Domains (1) summary
      cl28181
      Location:139 → 1354
      AAA; ATPases associated with a variety of cellular activities
    Nucleotide Protein
    Heading Accession and Version

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