ATP20 F1F0 ATP synthase subunit g [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: ATP20
Official Full Name: F1F0 ATP synthase subunit g
Primary source: SGD:S000006224
Locus tag: YPR020W
See related: AllianceGenome:SGD:S000006224; FungiDB:YPR020W; VEuPathDB:YPR020W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Contributes to proton-transporting ATP synthase activity, rotational mechanism. Involved in cristae formation; protein-containing complex assembly; and proton motive force-driven ATP synthesis. Part of proton-transporting ATP synthase complex. Is active in mitochondrion. Orthologous to human ATP5MG (ATP synthase membrane subunit g) and ATP5MGL (ATP synthase membrane subunit g like). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ATP20 in Genome Data Viewer

Location:: chromosome: XVI

Exon count:: 1

Sequence:: Chromosome: XVI; NC_001148.4 (599870..600217)

Chromosome XVI - NC_001148.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data show that Su k (Atp19) and Su i (Atp18) are involved in the assembly of Su e (Atp21) and Su g (Atp20) F(1)F(o)-ATP synthase dimers and oligomers.
Title: Stepwise assembly of dimeric F(1)F(o)-ATP synthase in mitochondria involves the small F(o)-subunits k and i.
Association of Su e and Su g with monomeric F(1)F(o)-ATP synthase represents an initial step of oligomer formation.
Title: Mitochondrial F1Fo-ATP synthase: the small subunits e and g associate with monomeric complexes to trigger dimerization.
Results propose a model in which the antagonism between Fcj1 and Su e/g locally modulates the F(1)F(O) oligomeric state, thereby controlling membrane curvature of cristae to generate crista junctions and cristae tips.
Title: Formation of cristae and crista junctions in mitochondria depends on antagonism between Fcj1 and Su e/g.
the GXXXG motif may not be the sole basis for a Su g-Su e interaction within F1F0-ATPase
Title: The yeast F(1)F(0)-ATP synthase: analysis of the molecular organization of subunit g and the importance of a conserved GXXXG motif.
the conserved GXXXG motif of the membrane-spanning segment of subunit g has a role in the supramolecular species of yeast ATP synthase
Title: The modification of the conserved GXXXG motif of the membrane-spanning segment of subunit g destabilizes the supramolecular species of yeast ATP synthase.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables proton transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
contributes_to proton-transporting ATP synthase activity, rotational mechanism	IBA Inferred from Biological aspect of Ancestor more info
contributes_to proton-transporting ATP synthase activity, rotational mechanism	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in ATP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in cristae formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein-containing complex assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proton motive force-driven ATP synthesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in proton motive force-driven ATP synthesis	IDA Inferred from Direct Assay more info	PubMed
involved_in proton motive force-driven ATP synthesis	IEA Inferred from Electronic Annotation more info
involved_in proton motive force-driven ATP synthesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proton transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrion	IMP Inferred from Mutant Phenotype more info	PubMed
part_of proton-transporting ATP synthase complex	IMP Inferred from Mutant Phenotype more info	PubMed
part_of proton-transporting ATP synthase complex, coupling factor F(o)	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: F1F0 ATP synthase subunit g

NP_015345.1

Subunit g of the mitochondrial F1F0 ATP synthase; reversibly phosphorylated on two residues; unphosphorylated form is required for dimerization of the ATP synthase complex, which in turn determines oligomerization of the complex and the shape of inner membrane cristae

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001148.4 Reference assembly

Range

599870..600217

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001184117.1 → NP_015345.1 TPA: F1F0 ATP synthase subunit g [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_015345.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W430, Q12233

UniProtKB/TrEMBL

A6ZWR3, B3LL81, C7GQB8, C8ZJ45, G2WPJ8, N1NVJ4

Conserved Domains (1) summary

pfam04718
Location:14 → 112

ATP-synt_G; Mitochondrial ATP synthase g subunit