PKC1 protein kinase C [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: PKC1
Official Full Name: protein kinase C
Primary source: SGD:S000000201
Locus tag: YBL105C
See related: AllianceGenome:SGD:S000000201; FungiDB:YBL105C; VEuPathDB:YBL105C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: CLY15; CLY5; CLY7; HPO2; RSF8; STT1
Summary: Enables diacylglycerol-dependent serine/threonine kinase activity. Involved in several processes, including cellular bud neck septin ring organization; pexophagy; and positive regulation of cytoplasmic mRNA processing body assembly. Located in several cellular components, including cytoplasmic stress granule; cytoskeleton; and site of polarized growth. Human ortholog(s) of this gene implicated in several diseases, including autoimmune lymphoproliferative syndrome type 3; carcinoma (multiple); high grade glioma (multiple); spinocerebellar ataxia type 14; and steatotic liver disease. Orthologous to several human genes including PRKCA (protein kinase C alpha). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See PKC1 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 1

Sequence:: Chromosome: II; NC_001134.8 (14241..17696, complement)

Chromosome II - NC_001134.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Stress granules sense metabolic stress at the plasma membrane and potentiate recovery by storing active Pkc1.
Title: Stress granules sense metabolic stress at the plasma membrane and potentiate recovery by storing active Pkc1.
Pkc1 triggers dispersal of Ste5 from mating projections upon mechanically induced stress and during cell-cell fusion, leading to inhibition of the MAPK Fus3.
Title: Mechanical stress impairs pheromone signaling via Pkc1-mediated regulation of the MAPK scaffold Ste5.
Pkc1 in cooperation with calcineurin mediates cell survival under compressive mechanical stress.
Title: Protein kinase C and calcineurin cooperatively mediate cell survival under compressive mechanical stress.
The Pkc1-mediated degradation of Pah1 was attenuated in the cho1Delta mutant, which is deficient in PS synthase, supporting the notion that the phospholipid regulates Pkc1 activity in vivo.
Title: Phosphorylation of lipid metabolic enzymes by yeast protein kinase C requires phosphatidylserine and diacylglycerol.
Constitutively active Pkc1 can drive cells through a mitotic checkpoint arrest, which suggests that Pkc1-dependent activation of PP2A(Cdc55) plays a critical role in checkpoint signaling.
Title: Protein Kinase C Controls Binding of Igo/ENSA Proteins to Protein Phosphatase 2A in Budding Yeast.
Pkc1 also enhances H3T45 phosphorylation and this modification is required for H3K56 acetylation.
Title: Protein kinase C coordinates histone H3 phosphorylation and acetylation.
Authors propose that Rho1 and Pkc1 coordinate septin ring assembly with membrane and cell wall remodeling partly by controlling Syp1 residence at the bud neck.
Title: Rho1- and Pkc1-dependent phosphorylation of the F-BAR protein Syp1 contributes to septin ring assembly.
The Mih1 is negatively regulated by Pkc1-mediated phosphorylation, which excludes it from the nucleus under certain conditions.
Title: Mih1/Cdc25 is negatively regulated by Pkc1 in Saccharomyces cerevisiae.
This study connects the Pkc1 protein to the maintenance of genome integrity in response to genotoxic stresses.
Title: Protein kinase C controls activation of the DNA integrity checkpoint.
activation of PKC-MAPK signaling by interruption of inositol sphingolipid synthesis leads to increased Sir2p-dependent silencing and is dependent upon the de novo and salvage pathways for NAD(+) synthesis but is not correlated with cellular NAD(+) levels
Title: Activation of protein kinase C-mitogen-activated protein kinase signaling in response to inositol starvation triggers Sir2p-dependent telomeric silencing in yeast.

Submit: New GeneRIF Correction See all GeneRIFs (24)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables calcium,diacylglycerol-dependent serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables diacylglycerol-dependent serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables diacylglycerol-dependent serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables diacylglycerol-dependent, calcium-independent serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	RCA inferred from Reviewed Computational Analysis more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular bud neck septin ring organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to starvation	IDA Inferred from Direct Assay more info	PubMed
involved_in fungal-type cell wall biogenesis	IEA Inferred from Electronic Annotation more info
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pexophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cytoplasmic mRNA processing body assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of fungal-type cell wall organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of nuclear-transcribed mRNA poly(A) tail shortening	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in stress granule assembly	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cellular bud neck	HDA more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic stress granule	IDA Inferred from Direct Assay more info	PubMed
located_in cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	HDA more info	PubMed
located_in prospore septin filament array	HDA more info	PubMed
located_in site of polarized growth	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: protein kinase C

NP_009445.2

EC 2.7.11.13

Protein serine/threonine kinase; essential for cell wall remodeling during growth; localized to sites of polarized growth and the mother-daughter bud neck; homolog of the alpha, beta, and gamma isoforms of mammalian protein kinase C (PKC)

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001134.8 Reference assembly

Range

14241..17696 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001178345.2 → NP_009445.2 TPA: protein kinase C [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_009445.2

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VPP8, P24583

UniProtKB/TrEMBL

A6ZKJ9, B3LNN5, B5VDP0, C7GSE0, C8Z3T7, N1P9K6

Conserved Domains (6) summary

cd08689
Location:211 → 319

C2_fungal_Pkc1p; C2 domain found in protein kinase C (Pkc1p) in Saccharomyces cerevisiae

cd11620
Location:110 → 181

HR1_PKC-like_2_fungi; Second Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of fungal Protein Kinase C-like proteins

cd11621
Location:1 → 72

HR1_PKC-like_1_fungi; First Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of fungal Protein Kinase C-like proteins

cd05570
Location:828 → 1145

STKc_PKC; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase C

cd20822
Location:413 → 464

C1_ScPKC1-like_rpt1; first protein kinase C conserved region 1 (C1 domain) found in Saccharomyces cerevisiae protein kinase C-like 1 (ScPKC1) and similar proteins

cd20823
Location:478 → 536

C1_ScPKC1-like_rpt2; second protein kinase C conserved region 1 (C1 domain) found in Saccharomyces cerevisiae protein kinase C-like 1 (ScPKC1) and similar proteins