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    SDH6 Sdh6p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851986, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SDH6
    Official Full Name
    Sdh6p
    Primary source
    SGD:S000007605
    Locus tag
    YDR379C-A
    See related
    AllianceGenome:SGD:S000007605; FungiDB:YDR379C-A; VEuPathDB:YDR379C-A
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in mitochondrial respiratory chain complex II assembly. Located in mitochondrion. Used to study mitochondrial complex II deficiency. Human ortholog(s) of this gene implicated in mitochondrial complex II deficiency. Orthologous to human SDHAF1 (succinate dehydrogenase complex assembly factor 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SDH6 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (1233278..1233517, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene U4/U6-U5 snRNP complex subunit LSM6 Neighboring gene GTPase-activating protein RGA2 Neighboring gene phenylpyruvate decarboxylase ARO10 Neighboring gene RNA-binding protein YRA1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. SDHAF1, encoding a LYR complex-II specific assembly factor, is mutated in SDH-defective infantile leukoencephalopathy. Ghezzi D, et al. Nat Genet, 2009 Jun. PMID 19465911
    2. ACP Acylation Is an Acetyl-CoA-Dependent Modification Required for Electron Transport Chain Assembly. Van Vranken JG, et al. Mol Cell, 2018 Aug 16. PMID 30118679, Free PMC Article
    3. The LYR factors SDHAF1 and SDHAF3 mediate maturation of the iron-sulfur subunit of succinate dehydrogenase. Na U, et al. Cell Metab, 2014 Aug 5. PMID 24954417, Free PMC Article
    4. Identification and characterization of genes related to the production of organic acids in yeast. Yoshida S, et al. J Biosci Bioeng, 2012 May. PMID 22277779
    5. ATP synthase interactome analysis identifies a new subunit l as a modulator of permeability transition pore in yeast. Panja C, et al. Sci Rep, 2023 Mar 7. PMID 36882574, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial respiratory chain complex II assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial respiratory chain complex II assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial respiratory chain complex II assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondrial respiratory chain complex II assembly IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Sdh6p
    NP_076888.3
    • Mitochondrial protein involved in assembly of succinate dehydrogenase; has a role in maturation of the Sdh2p subunit; member of the LYR protein family; mutations in human ortholog SDHAF1 are associated with infantile leukoencephalopathy

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      1233278..1233517 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184471.3 → NP_076888.3  TPA: Sdh6p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_076888.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A6ZYX9, D6VT12, Q3E785
      UniProtKB/TrEMBL
      B3LFS2, C7GMF6, C8Z5U3, G2WBB7, N1P5F2
      Conserved Domains (1) summary
      cd20268
      Location:6 → 69
      Complex1_LYR_SDHAF1_LYRM8; LYR (leucine-tyrosine-arginine) motif found in mitochondrial succinate dehydrogenase assembly factor 1 (SDHAF1) and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3E785.1

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