AVT4 Avt4p [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: AVT4
Official Full Name: Avt4p
Primary source: SGD:S000005045
Locus tag: YNL101W
See related: AllianceGenome:SGD:S000005045; FungiDB:YNL101W; VEuPathDB:YNL101W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables L-glutamine transmembrane transporter activity; L-isoleucine transmembrane transporter activity; and L-tyrosine transmembrane transporter activity. Involved in amino acid transmembrane export from vacuole. Located in fungal-type vacuole membrane and vacuole-mitochondrion membrane contact site. Human ortholog(s) of this gene implicated in iminoglycinuria. Orthologous to several human genes including SLC36A1 (solute carrier family 36 member 1); SLC36A2 (solute carrier family 36 member 2); and SLC36A3 (solute carrier family 36 member 3). [provided by Alliance of Genome Resources, Dec 2024]
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Chromosome XIV - NC_001146.8 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

Avt4p is a vacuolar amino acid exporter involving in the recycling of basic amino acids
Title: Vacuolar transporter Avt4 is involved in excretion of basic amino acids from the vacuoles of Saccharomyces cerevisiae.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables L-glutamine transmembrane transporter activity	IGI Inferred from Genetic Interaction more info	PubMed
enables L-glutamine transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables L-isoleucine transmembrane transporter activity	IGI Inferred from Genetic Interaction more info	PubMed
enables L-isoleucine transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables L-tyrosine transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables L-tyrosine transmembrane transporter activity	IGI Inferred from Genetic Interaction more info	PubMed
enables L-tyrosine transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in L-alpha-amino acid transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in amino acid transmembrane export from vacuole	IGI Inferred from Genetic Interaction more info	PubMed
involved_in amino acid transmembrane export from vacuole	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in amino acid transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in amino acid transport	IEA Inferred from Electronic Annotation more info
involved_in branched-chain amino acid transport	IEA Inferred from Electronic Annotation more info
involved_in glutamine transport	IEA Inferred from Electronic Annotation more info
involved_in neutral amino acid transport	IEA Inferred from Electronic Annotation more info
involved_in organic cation transport	IEA Inferred from Electronic Annotation more info
involved_in tyrosine transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in fungal-type vacuole	IDA Inferred from Direct Assay more info	PubMed
located_in fungal-type vacuole membrane	IMP Inferred from Mutant Phenotype more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in vacuolar membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in vacuolar membrane	IEA Inferred from Electronic Annotation more info
located_in vacuole	IEA Inferred from Electronic Annotation more info
located_in vacuole-mitochondrion membrane contact site	IDA Inferred from Direct Assay more info	PubMed

NP_014298.1

Vacuolar transporter; exports large neutral amino acids from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters; localizes to sites of contact between the vacuole and mitochondria (vCLAMPs)