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    rho4 Rho family GTPase Rho4 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 3361476, updated on 18-Sep-2024

    Summary

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    Official Symbol
    rho4
    Official Full Name
    Rho family GTPase Rho4
    Primary source
    PomBase:SPAC16A10.04
    Locus tag
    SPOM_SPAC16A10.04
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See rho4 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    6
    Sequence:
    Chromosome: I; NC_003424.3 (3087013..3088619)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene tRNA-Lys Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene DASH complex subunit Dad1 Neighboring gene Smc5-6 complex non-SMC SUMO ligase subunit Nse2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Novel Rho GTPase involved in cytokinesis and cell wall integrity in the fission yeast Schizosaccharomyces pombe. Santos B, et al. Eukaryot Cell, 2003 Jun. PMID 12796297, Free PMC Article
    2. Septum formation is regulated by the RHO4-specific exchange factors BUD3 and RGF3 and by the landmark protein BUD4 in Neurospora crassa. Justa-Schuch D, et al. Mol Microbiol, 2010 Apr. PMID 20199606
    3. Rho4 GTPase is involved in secretion of glucanases during fission yeast cytokinesis. Santos B, et al. Eukaryot Cell, 2005 Oct. PMID 16215171, Free PMC Article
    4. The small GTPase Rho4 is involved in controlling cell morphology and septation in fission yeast. Nakano K, et al. Genes Cells, 2003 Apr. PMID 12653963
    5. Geranylgeranyltransferase Cwg2-Rho4/Rho5 module is implicated in the Pmk1 MAP kinase-mediated cell wall integrity pathway in fission yeast. Doi A, et al. Genes Cells, 2015 Apr. PMID 25651781

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data indicate that Rho guanine nucleotide exchange factors Gef3 interacts with the septin complex and activates Rho4 GTPase for septation during cytokinesis.
      Title: The Rho-GEF Gef3 interacts with the septin complex and activates the GTPase Rho4 during fission yeast cytokinesis.
    2. Rho4 and Rho5 deletion cells exhibited the vic phenotype and cell wall integrity defects, shared phenotypes among the components of the Pmk1 MAPK pathway.
      Title: Geranylgeranyltransferase Cwg2-Rho4/Rho5 module is implicated in the Pmk1 MAP kinase-mediated cell wall integrity pathway in fission yeast.
    3. These results provide evidence that Rho4p is involved in the regulation of Eng1p and Agn1p secretion during cytokinesis.
      Title: Rho4 GTPase is involved in secretion of glucanases during fission yeast cytokinesis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in division septum assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in fungal-type cell wall organization or biogenesis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of septum digestion after cytokinesis EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in primary cell septum disassembly TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell cortex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cell division site EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in cytoplasmic side of plasma membrane NAS
    Non-traceable Author Statement
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in division septum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Rho family GTPase Rho4

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      3087013..3088619
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001019469.3 → NP_001018257.1  Rho family GTPase Rho4 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_001018257.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q874R1
      Conserved Domains (2) summary
      smart00174
      Location:17 → 185
      RHO; Rho (Ras homology) subfamily of Ras-like small GTPases
      cd04132
      Location:12 → 189
      Rho4_like; Ras homology family 4 (Rho4) of small guanosine triphosphatases (GTPases)-like
    Nucleotide Protein
    Heading Accession and Version

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