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    cdc18 MCM loader [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2540013, updated on 18-Sep-2024

    Summary

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    Official Symbol
    cdc18
    Official Full Name
    MCM loader
    Primary source
    PomBase:SPBC14C8.07c
    Locus tag
    SPOM_SPBC14C8.07C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See cdc18 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_003423.3 (2215955..2217984, complement)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ARP2/3 actin-organizing complex WD repeat subunit Sop2 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene protein tam10 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. p65cdc18 plays a major role controlling the initiation of DNA replication in fission yeast. Nishitani H, et al. Cell, 1995 Nov 3. PMID 8521469
    2. The regulation of competence to replicate in meiosis by Cdc6 is conserved during evolution. Lemaître JM, et al. Mol Reprod Dev, 2004 Sep. PMID 15278909
    3. Sap1 is a replication-initiation factor essential for the assembly of pre-replicative complex in the fission yeast Schizosaccharomyces pombe. Guan L, et al. J Biol Chem, 2017 Apr 14. PMID 28223353, Free PMC Article
    4. The fission yeast cdc18+ gene product couples S phase to START and mitosis. Kelly TJ, et al. Cell, 1993 Jul 30. PMID 7916658
    5. Chromatin binding of the fission yeast replication factor mcm4 occurs during anaphase and requires ORC and cdc18. Kearsey SE, et al. EMBO J, 2000 Apr 3. PMID 10747035, Free PMC Article

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The cdc18 as a binding partner of Swi6 has no silencing defect at the centromere, but changes Swi6 distribution and accelerates the timing of centromere replication.
      Title: S. pombe replication protein Cdc18 (Cdc6) interacts with Swi6 (HP1) heterochromatin protein: region specific effects and replication timing in the centromere.
    2. An elevated level of Cdc18 activates the Rad3-dependent checkpoint either directly or indirectly, and additionally causes expansion of the rDNA repeats on Chromosome III.
      Title: Cdc18/CDC6 activates the Rad3-dependent checkpoint in the fission yeast.
    3. demonstrated that within the promoter of cdc18+, a representative pre-S gene, the orientation and spacing of MCBs are crucial for activation and cell-cycle dependence
      Title: Transcription of the Schizosaccharomyces pombe gene cdc18+: roles of MCB elements and the DSC1 complex.
    4. S phase arrest activates the S phase checkpoint blocking mitosis onset and inhibiting Cdc18 degradation.
      Title: Cdc18 enforces long-term maintenance of the S phase checkpoint by anchoring the Rad3-Rad26 complex to chromatin.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables ATP binding ISM
    Inferred from Sequence Model
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA replication origin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA replication initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in MCM complex loading IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic DNA replication checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic DNA replication checkpoint signaling IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in mitotic pre-replicative complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA replication initiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of protein localization to chromatin IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of nuclear pre-replicative complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nuclear replication fork IC
    Inferred by Curator
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    MCM loader

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      2215955..2217984 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001021818.3 → NP_595910.1  MCM loader [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_595910.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P41411
      Conserved Domains (3) summary
      cd00009
      Location:170 → 333
      AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
      cd08768
      Location:478 → 560
      Cdc6_C; Winged-helix domain of essential DNA replication protein Cell division control protein (Cdc6), which mediates DNA binding
      COG1474
      Location:169 → 571
      CDC6; Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair]
    Nucleotide Protein
    Heading Accession and Version

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