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    mis18 kinetochore protein Mis18 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2538763, updated on 18-Sep-2024

    Summary

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    Official Symbol
    mis18
    Official Full Name
    kinetochore protein Mis18
    Primary source
    PomBase:SPCC970.12
    Locus tag
    SPOM_SPCC970.12
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See mis18 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    6
    Sequence:
    Chromosome: III; NC_003421.2 (513931..514807, complement)

    Chromosome III - NC_003421.2Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene cytochrome b5 reductase Neighboring gene mannan endo-1,6-alpha-mannosidase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene DNA repair endonuclease XPF Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003421.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Centromere targeting of Mis18 requires the interaction with DNA and H2A-H2B in fission yeast. Zhang M, et al. Cell Mol Life Sci, 2021 Jan. PMID 32318758, Free PMC Article
    2. Fission Yeast CENP-C (Cnp3) Plays a Role in Restricting the Site of CENP-A Accumulation. Suma M, et al. G3 (Bethesda), 2018 Jul 31. PMID 29925533, Free PMC Article
    3. Direct recruitment of Mis18 to interphase spindle pole bodies promotes CENP-A chromatin assembly. London N, et al. Curr Biol, 2023 Oct 9. PMID 37714149
    4. Centromere localization and function of Mis18 requires Yippee-like domain-mediated oligomerization. Subramanian L, et al. EMBO Rep, 2016 Apr. PMID 26921242, Free PMC Article
    5. Fission yeast Scm3: A CENP-A receptor required for integrity of subkinetochore chromatin. Pidoux AL, et al. Mol Cell, 2009 Feb 13. PMID 19217404, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Direct recruitment of Mis18 to interphase spindle pole bodies promotes CENP-A chromatin assembly.
      Title: Direct recruitment of Mis18 to interphase spindle pole bodies promotes CENP-A chromatin assembly.
    2. Centromere targeting of Mis18 requires the interaction with DNA and H2A-H2B in fission yeast.
      Title: Centromere targeting of Mis18 requires the interaction with DNA and H2A-H2B in fission yeast.
    3. Results confirm that the binding of Mis19 to Mis18 requires the N terminus of Mis19 and two Mis18 C-terminus.
      Title: Subunit interactions and arrangements in the fission yeast Mis16-Mis18-Mis19 complex.
    4. findings show that the oligomerization of S. pombe Mis18, mediated via its conserved N-terminal Yippee-like domain, is crucial for its centromere localization and function
      Title: Centromere localization and function of Mis18 requires Yippee-like domain-mediated oligomerization.
    5. Mis16-Mis18-Mis19-Mis20 CENP-A-recruiting complex, which is functional in the G1-S phase, may be counteracted by the SWI/SNF chromatin-remodeling complex and non-sense-mediated mRNA decay, which may prevent CENP-A deposition at the centromere.
      Title: Schizosaccharomyces pombe centromere protein Mis19 links Mis16 and Mis18 to recruit CENP-A through interacting with NMD factors and the SWI/SNF complex.
    6. we report that the Mis16-Mis18 complex is required for centromere localization of Scm3(Sp)
      Title: Fission yeast Scm3 mediates stable assembly of Cnp1/CENP-A into centromeric chromatin.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables zinc ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in CENP-A containing chromatin assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in CENP-A containing chromatin assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chromosome segregation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of CENP-A recruiting complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in chromosome, centromeric region IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in kinetochore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    kinetochore protein Mis18

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003421.2 Reference assembly

      Range
      513931..514807 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001022847.3 → NP_587854.2  kinetochore protein Mis18 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_587854.2

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q9P802
      Conserved Domains (1) summary
      pfam03226
      Location:21 → 115
      Yippee-Mis18; Yippee zinc-binding/DNA-binding /Mis18, centromere assembly
    Nucleotide Protein
    Heading Accession and Version

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