cdc22 ribonucleoside reductase large subunit Cdc22 [Schizosaccharomyces pombe (fission yeast)] - Gene

Summary

Official Symbol: cdc22
Official Full Name: ribonucleoside reductase large subunit Cdc22
Primary source: PomBase:SPAC1F7.05
Locus tag: SPOM_SPAC1F7.05
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Schizosaccharomyces pombe (strain: 972h-)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Chromosome I - NC_003424.3 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

Spd1 accumulation causes genome instability independently of cdc22 activity.
Title: Spd1 accumulation causes genome instability independently of ribonucleotide reductase activity but functions to protect the genome when deoxynucleotide pools are elevated.
Spd1p inhibits fission yeast ribonucleotide reductase activity by interacting with the Cdc22p.
Title: The Schizosaccharomyces pombe replication inhibitor Spd1 regulates ribonucleotide reductase activity and dNTPs by binding to the large Cdc22 subunit.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables ATP binding	IBA Inferred from Biological aspect of Ancestor more info
contributes_to CDP reductase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in CDP metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in dCDP biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in dTTP biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in deoxyribonucleotide biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	HDA more info	PubMed
is_active_in cytosol	HDA more info	PubMed
part_of ribonucleoside-diphosphate reductase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of ribonucleoside-diphosphate reductase complex	IPI Inferred from Physical Interaction more info	PubMed

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The following sections contain reference sequences that belong to a specific genome build. Explain