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    AQY2 Aqy2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850674, updated on 9-Dec-2024

    Summary

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    Official Symbol
    AQY2
    Official Full Name
    Aqy2p
    Primary source
    SGD:S000003975
    Locus tag
    YLL052C
    See related
    AllianceGenome:SGD:S000003975; FungiDB:YLL052C; VEuPathDB:YLL052C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables water channel activity. Involved in transmembrane transport and water transport. Located in endoplasmic reticulum membrane and plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See AQY2 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (35912..36361, complement)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Yct1p Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene putative ferric-chelate reductase Neighboring gene cofilin

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Aquaporins in Saccharomyces. Genetic and functional distinctions between laboratory and wild-type strains. Bonhivers M, et al. J Biol Chem, 1998 Oct 16. PMID 9765289
    2. Water channel activity of radish plasma membrane aquaporins heterologously expressed in yeast and their modification by site-directed mutagenesis. Suga S, et al. Plant Cell Physiol, 2004 Jul. PMID 15295065
    3. Aquaporins in yeasts and filamentous fungi. Pettersson N, et al. Biol Cell, 2005 Jul. PMID 15966864
    4. Aquaporins in Saccharomyces cerevisiae wine yeast. Karpel JE, et al. FEMS Microbiol Lett, 2006 Apr. PMID 16553841
    5. Water channels are important for osmotic adjustments of yeast cells at low temperature. Soveral G, et al. Microbiology (Reading), 2006 May. PMID 16622068

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Several genomic signatures at AQY1 and/or AQY2 reveal low variation surrounding these loci within strains of the same haplotype, but high variation between strain groups
      Title: Incipient balancing selection through adaptive loss of aquaporins in natural Saccharomyces cerevisiae populations.
    2. Study shows that Aqy2 is involved in controlling cell surface properties and that its expression is controlled by osmoregulatory and morphogenic signalling pathways.
      Title: Expression of the yeast aquaporin Aqy2 affects cell surface properties under the control of osmoregulatory and morphogenic signalling pathways.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables water channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in transmembrane transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in water transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol HDA PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Aqy2p
    NP_013048.1
    • Water channel that mediates water transport across cell membranes; only expressed in proliferating cells; controlled by osmotic signals; may be involved in freeze tolerance; disrupted by a stop codon in many S. cerevisiae strains

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      35912..36361 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181872.1 → NP_013048.1  TPA: Aqy2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013048.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A7A0K8, B3LTC5, C7GNE3, C8ZCS3, D6VXV6, O93938, P0CD90, Q12258, Q12302, Q9C411
      UniProtKB/TrEMBL
      D3W8P2
      Conserved Domains (1) summary
      COG0580
      Location:1 → 149
      GlpF; Glycerol uptake facilitator and related aquaporins (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P0CD90.1

    Gene LinkOut

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