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    mis16 histone H4 chaperone, CENP-A recruiting complex CENP-A chaperone Mis16 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2539214, updated on 18-Sep-2024

    Summary

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    Official Symbol
    mis16
    Official Full Name
    histone H4 chaperone, CENP-A recruiting complex CENP-A chaperone Mis16
    Primary source
    PomBase:SPCC1672.10
    Locus tag
    SPOM_SPCC1672.10
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See mis16 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    3
    Sequence:
    Chromosome: III; NC_003421.2 (584126..585893)

    Chromosome III - NC_003421.2Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene P-type ATPase P5 type Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003421.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mis16 Switches Function from a Histone H4 Chaperone to a CENP-A(Cnp1)-Specific Assembly Factor through Eic1 Interaction. An S, et al. Structure, 2018 Jul 3. PMID 29804820, Free PMC Article
    2. Mis16 Independently Recognizes Histone H4 and the CENP-ACnp1-Specific Chaperone Scm3sp. An S, et al. J Mol Biol, 2015 Oct 9. PMID 26343758
    3. Schizosaccharomyces pombe Hat1 (Kat1) is associated with Mis16 and is required for telomeric silencing. Tong K, et al. Eukaryot Cell, 2012 Sep. PMID 22771823, Free PMC Article
    4. The kinetochore protein Kis1/Eic1/Mis19 ensures the integrity of mitotic spindles through maintenance of kinetochore factors Mis6/CENP-I and CENP-A. Hirai H, et al. PLoS One, 2014. PMID 25375240, Free PMC Article
    5. Kinetochore Components Required for Centromeric Chromatin Assembly Are Impacted by Msc1 in Schizosaccharomyces pombe. Gao C, et al. Genetics, 2017 Oct. PMID 28827290, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results find that the C terminus of Mis19 binds to Mis16 by engaging the histone H4-binding pocket on Mis16.
      Title: Subunit interactions and arrangements in the fission yeast Mis16-Mis18-Mis19 complex.
    2. Ccp1 interacts with CENP-A and is recruited to centromeres at the end of mitosis in a Mis16-dependent manner.
      Title: Ccp1 Homodimer Mediates Chromatin Integrity by Antagonizing CENP-A Loading.
    3. Mis16-Mis18-Mis19-Mis20 CENP-A-recruiting complex, which is functional in the G1-S phase, may be counteracted by the SWI/SNF chromatin-remodeling complex and non-sense-mediated mRNA decay, which may prevent CENP-A deposition at the centromere.
      Title: Schizosaccharomyces pombe centromere protein Mis19 links Mis16 and Mis18 to recruit CENP-A through interacting with NMD factors and the SWI/SNF complex.
    4. Mis16 is physically associated with Hat1.
      Title: Schizosaccharomyces pombe Hat1 (Kat1) is associated with Mis16 and is required for telomeric silencing.
    5. we report that the Mis16-Mis18 complex is required for centromere localization of Scm3(Sp)
      Title: Fission yeast Scm3 mediates stable assembly of Cnp1/CENP-A into centromeric chromatin.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables H3-H4 histone complex chaperone activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in CENP-A containing chromatin assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chromatin remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of CENP-A recruiting complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in chromosome, centromeric region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in kinetochore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    histone H4 chaperone, CENP-A recruiting complex CENP-A chaperone Mis16

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003421.2 Reference assembly

      Range
      584126..585893
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001022873.3 → NP_587881.1  histone H4 chaperone, CENP-A recruiting complex CENP-A chaperone Mis16 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_587881.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O94244
      Conserved Domains (3) summary
      cd00200
      Location:130 → 418
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:135 → 180
      7WD40; WD40 repeat [structural motif]
      pfam12265
      Location:28 → 98
      CAF1C_H4-bd; Histone-binding protein RBBP4 or subunit C of CAF1 complex
    Nucleotide Protein
    Heading Accession and Version

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