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    SOV1 Sov1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855088, updated on 17-Dec-2024

    Summary

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    Official Symbol
    SOV1
    Official Full Name
    Sov1p
    Primary source
    SGD:S000004670
    Locus tag
    YMR066W
    See related
    AllianceGenome:SGD:S000004670; FungiDB:YMR066W; VEuPathDB:YMR066W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables translation activator activity. Involved in mitochondrial translation. Acts upstream of or within mitochondrial ribosome assembly. Located in mitochondrion. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SOV1 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (401541..404237)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene Aep1p Neighboring gene Kar5p Neighboring gene Ubx4p Neighboring gene Avo2p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The translational activator Sov1 coordinates mitochondrial gene expression with mitoribosome biogenesis. Seshadri SR, et al. Nucleic Acids Res, 2020 Jul 9. PMID 32449921, Free PMC Article
    2. The yeast protein Mam33 functions in the assembly of the mitochondrial ribosome. Hillman GA, et al. J Biol Chem, 2019 Jun 21. PMID 31053642, Free PMC Article
    3. The SUN protein Mps3 is required for spindle pole body insertion into the nuclear membrane and nuclear envelope homeostasis. Friederichs JM, et al. PLoS Genet, 2011 Nov. PMID 22125491, Free PMC Article
    4. The clathrin adaptor Gga2p is a phosphatidylinositol 4-phosphate effector at the Golgi exit. Demmel L, et al. Mol Biol Cell, 2008 May. PMID 18287542, Free PMC Article
    5. Absence of mitochondrial translation control proteins extends life span by activating sirtuin-dependent silencing. Caballero A, et al. Mol Cell, 2011 May 6. PMID 21549315

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The translational activator Sov1 coordinates mitochondrial gene expression with mitoribosome biogenesis.
      Title: The translational activator Sov1 coordinates mitochondrial gene expression with mitoribosome biogenesis.
    2. Data show that that inactivating SOV1, a member of the yeast mitochondrial translation control (MTC) module, causes a robust Sir2-dependent extension of replicative life span.
      Title: Absence of mitochondrial translation control proteins extends life span by activating sirtuin-dependent silencing.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables translation activator activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within mitochondrial ribosome assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondrial translation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Sov1p
    NP_013782.1
    • Translational activator involved in mitochondrial translation; role in mitochondrial ribosome assembly

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      401541..404237
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182564.1 → NP_013782.1  TPA: Sov1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013782.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VZP0, Q04748
      UniProtKB/TrEMBL
      G2WKB4
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q04748.1

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