SLH1 putative RNA helicase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: SLH1
Official Full Name: putative RNA helicase
Primary source: SGD:S000003503
Locus tag: YGR271W
See related: AllianceGenome:SGD:S000003503; FungiDB:YGR271W; VEuPathDB:YGR271W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: RQT2
Summary: Enables ATP hydrolysis activity. Involved in cytoplasmic translation; regulation of translation; and rescue of stalled ribosome. Located in cytoplasmic stress granule. Is active in cytosolic ribosome. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder. Orthologous to human ASCC3 (activating signal cointegrator 1 complex subunit 3). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See SLH1 in Genome Data Viewer

Location:: chromosome: VII

Exon count:: 1

Sequence:: Chromosome: VII; NC_001139.9 (1031791..1037694)

Chromosome VII - NC_001139.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

premature arrest at ribosome stalling sequences still occurred robustly in the absence of Asc1, Hel2, and Slh1. However, these three factors were required for the ribosome quality control complex to modify the nascent chain.
Title: Asc1, Hel2, and Slh1 couple translation arrest to nascent chain degradation.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IDA Inferred from Direct Assay more info	PubMed
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATP-dependent H2AZ histone chaperone activity	IEA Inferred from Electronic Annotation more info
enables ATP-dependent H3-H4 histone complex chaperone activity	IEA Inferred from Electronic Annotation more info
enables DNA clamp loader activity	IEA Inferred from Electronic Annotation more info
enables RNA helicase activity	IEA Inferred from Electronic Annotation more info
enables RNA helicase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables chromatin extrusion motor activity	IEA Inferred from Electronic Annotation more info
enables cohesin loader activity	IEA Inferred from Electronic Annotation more info
enables helicase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables mRNA binding	HDA more info	PubMed
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chromatin looping	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in cytoplasmic translation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in defense response to virus	IEA Inferred from Electronic Annotation more info
involved_in regulation of translation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in rescue of stalled ribosome	IDA Inferred from Direct Assay more info	PubMed
involved_in ribosome disassembly	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic stress granule	HDA more info	PubMed
located_in cytosol	IEA Inferred from Electronic Annotation more info
is_active_in cytosolic ribosome	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: putative RNA helicase

NP_011787.4

EC 3.6.4.13

Subunit of ribosome-associated quality control trigger complex (RQT); contains ATPase activity required for subunit dissociation of non-functional 80S ribosomes containing polyubiquitinated Rps3p, leading to Xrn1-dependent degradation of the non-functional 18S rRNA; blocks translation of non-poly(A) mRNAs; required to repress the propagation of dsRNA viruses; RNA helicase-family protein related to Ski2p; human homolog is ASCC3

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001139.9 Reference assembly

Range

1031791..1037694

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001181400.4 → NP_011787.4 TPA: putative RNA helicase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_011787.4

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VV48, P53327

UniProtKB/TrEMBL

B3LHX3, C7GNG3, C8Z9G4, N1P2Q6

Conserved Domains (2) summary

COG1204
Location:250 → 1059

BRR2; Replicative superfamily II helicase [Replication, recombination and repair]

cd18022
Location:1139 → 1327

DEXHc_ASCC3_2; C-terminal DEXH-box helicase domain of Activating signal cointegrator 1 complex subunit 3