STE11 mitogen-activated protein kinase kinase kinase STE11 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: STE11
Official Full Name: mitogen-activated protein kinase kinase kinase STE11
Primary source: SGD:S000004354
Locus tag: YLR362W
See related: AllianceGenome:SGD:S000004354; FungiDB:YLR362W; VEuPathDB:YLR362W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables MAP kinase kinase kinase activity and SAM domain binding activity. Involved in several processes, including intracellular signal transduction; invasive growth in response to glucose limitation; and pseudohyphal growth. Located in cytoplasm. Orthologous to human MAP3K19 (mitogen-activated protein kinase kinase kinase 19). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See STE11 in Genome Data Viewer

Location:: chromosome: XII

Exon count:: 1

Sequence:: Chromosome: XII; NC_001144.5 (849866..852019)

Chromosome XII - NC_001144.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Core promoter activity contributes to chromatin-based regulation of internal cryptic promoters.
Title: Core promoter activity contributes to chromatin-based regulation of internal cryptic promoters.
Mechanical stress signal is transmitted via Ste11.
Title: SCWISh network is essential for survival under mechanical pressure.
Our results confirm the existence of negative feedback systems targeting the protein levels of Ste11 and Msb2 and also hint at changes in the dissociation rates of intermediate signaling complexes
Title: Msb2 is a Ste11 membrane concentrator required for full activation of the HOG pathway.
The Ras-binding-domain-like region in the Ste11 protein that is required specifically for the kinase to function with Ste5 in the mating pathway
Title: Structurally unique interaction of RBD-like and PH domains is crucial for yeast pheromone signaling.
Data show that ubiquitin-protein ligases Ubr1 and Ubr2 have opposing roles in Ste11DeltaNK444R-GFP aggregation.
Title: A network of ubiquitin ligases is important for the dynamics of misfolded protein aggregates in yeast.
Ste11 regulates the FKS2 gene through its substrates and through Mpk1.
Title: Ste11p MEKK signals through HOG, mating, calcineurin and PKC pathways to regulate the FKS2 gene.
DSE1 binds Ste11. The interaction of Dse1 with both Gbeta and Ste11 may be designed to control cross talk between the pheromone and filamentation pathways.
Title: Dse1 may control cross talk between the pheromone and filamentation pathways in yeast.
These results demonstrate that the interfacial residues of the dimeric SAM domain of Ste11 are critically involved in its structural stability and binding to the Ste50 SAM domain.
Title: Equilibrium unfolding of the dimeric SAM domain of MAPKKK Ste11 from the budding yeast: role of the interfacial residues in structural stability and binding.
propose that Opy2p can serve as a membrane anchor for the Ste50p/Ste11p module in the activation of the HOG pathway
Title: Adaptor protein Ste50p links the Ste11p MEKK to the HOG pathway through plasma membrane association.
Yeast bearing mutations that prevented the heterotypic Ste11-Ste50 association in vitro presented signaling defects in the mating and high-osmolarity growth pathways
Title: Saccharomyces cerevisiae Ste50 binds the MAPKKK Ste11 through a head-to-tail SAM domain interaction.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables JUN kinase kinase kinase activity	IEA Inferred from Electronic Annotation more info
enables MAP kinase kinase kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables SAM domain binding	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase activity	HDA more info	PubMed
enables protein kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in JNK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in MAPK cascade	IEA Inferred from Electronic Annotation more info
involved_in cell integrity MAPK cascade	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cellular hyperosmotic response	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cellular hyperosmotic response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in invasive growth in response to glucose limitation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in osmosensory signaling pathway via Sho1 osmosensor	IGI Inferred from Genetic Interaction more info	PubMed
involved_in p38MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in p38MAPK cascade	IGI Inferred from Genetic Interaction more info	PubMed
involved_in p38MAPK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pheromone response MAPK cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in pheromone response MAPK cascade	IGI Inferred from Genetic Interaction more info	PubMed
involved_in pheromone response MAPK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pheromone-dependent signal transduction involved in conjugation with cellular fusion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pseudohyphal growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to pheromone	IEA Inferred from Electronic Annotation more info
involved_in signal transduction involved in filamentous growth	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: mitogen-activated protein kinase kinase kinase STE11

NP_013466.1

EC 2.7.11.25

Signal transducing MEK kinase; involved in pheromone response and pseudohyphal/invasive growth pathways where it phosphorylates Ste7p, and the high osmolarity response pathway, via phosphorylation of Pbs2p; regulated by Ste20p and Ste50p; protein abundance increases in response to DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001144.5 Reference assembly

Range

849866..852019

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001182251.1 → NP_013466.1 TPA: mitogen-activated protein kinase kinase kinase STE11 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_013466.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A7A1P0, D6VZ00, P23561

UniProtKB/TrEMBL

G2WJI0

Conserved Domains (3) summary

cd09534
Location:20 → 82

SAM_Ste11_fungal; SAM domain of Ste11_fungal subfamily

pfam14847
Location:121 → 224

Ras_bdg_2; Ras-binding domain of Byr2

cl21453
Location:415 → 712

PKc_like; Protein Kinases, catalytic domain