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    its3 1-phosphatidylinositol-4-phosphate 5-kinase Its3 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2542231, updated on 14-Nov-2024

    Summary

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    Official Symbol
    its3
    Official Full Name
    1-phosphatidylinositol-4-phosphate 5-kinase Its3
    Primary source
    PomBase:SPAC19G12.14
    Locus tag
    SPOM_SPAC19G12.14
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    mss4
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    Genomic context

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    See its3 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    3
    Sequence:
    Chromosome: I; NC_003424.3 (4072136..4075036)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene decaprenyl diphosphate synthase subunit 2 Dlp1 Neighboring gene protein Poz1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene trehalose-6-phosphate phosphatase Tpp1 Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Fission yeast Opy1 is an endogenous PI(4,5)P(2) sensor that binds to the phosphatidylinositol 4-phosphate 5-kinase Its3. Snider CE, et al. J Cell Sci, 2020 Dec 3. PMID 33172987, Free PMC Article
    2. Phosphatidylinositol 4-phosphate 5-kinase Its3 and calcineurin Ppb1 coordinately regulate cytokinesis in fission yeast. Zhang Y, et al. J Biol Chem, 2000 Nov 10. PMID 10950958
    3. Regulation of phosphatidylinositol 4-phosphate 5-kinase from Schizosaccharomyces pombe by casein kinase I. Vancurova I, et al. J Biol Chem, 1999 Jan 8. PMID 9873063
    4. Fission yeast myosin I facilitates PI(4,5)P(2)-mediated anchoring of cytoplasmic dynein to the cortex. Thankachan JM, et al. Proc Natl Acad Sci U S A, 2017 Mar 28. PMID 28292899, Free PMC Article
    5. Functional link between Rab GTPase-mediated membrane trafficking and PI4,5P2 signaling. Li C, et al. Genes Cells, 2014 Mar. PMID 24350606

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. a mechanism whereby PI4P5K signaling/localization is affected by Golgi membrane trafficking, proviing a functional link between the PI4,5P2 signaling and Rab-mediated trafficking.
      Title: Functional link between Rab GTPase-mediated membrane trafficking and PI4,5P2 signaling.
    2. Its3 PIP5K regulates cell integrity through a Plc1-mediated PKC-independent pathway, in addition to the Rho/PKC pathway
      Title: Phosphatidylinositol-4-phosphate 5-kinase regulates fission yeast cell integrity through a phospholipase C-mediated protein kinase C-independent pathway.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables 1-phosphatidylinositol-3-phosphate 4-kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables 1-phosphatidylinositol-4-phosphate 5-kinase activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables 1-phosphatidylinositol-4-phosphate 5-kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 1-phosphatidylinositol-4-phosphate 5-kinase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables 1-phosphatidylinositol-4-phosphate 5-kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phospholipid binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in dynein-driven meiotic oscillatory nuclear movement EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in phosphatidylinositol phosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphatidylinositol phosphate biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of mitotic cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cell division site IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    1-phosphatidylinositol-4-phosphate 5-kinase Its3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      4072136..4075036
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001019858.3 → NP_594429.1  1-phosphatidylinositol-4-phosphate 5-kinase Its3 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_594429.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O13853
      Conserved Domains (2) summary
      smart00330
      Location:294 → 662
      PIPKc; Phosphatidylinositol phosphate kinases
      COG5253
      Location:1 → 667
      MSS4; Phosphatidylinositol-4-phosphate 5-kinase [Signal transduction mechanisms]
    Nucleotide Protein
    Heading Accession and Version

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