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    HUL5 ubiquitin-ubiquitin ligase HUL5 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852736, updated on 9-Dec-2024

    Summary

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    Official Symbol
    HUL5
    Official Full Name
    ubiquitin-ubiquitin ligase HUL5
    Primary source
    SGD:S000003109
    Locus tag
    YGL141W
    See related
    AllianceGenome:SGD:S000003109; FungiDB:YGL141W; VEuPathDB:YGL141W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables ubiquitin-ubiquitin ligase activity. Involved in several processes, including cellular response to heat; free ubiquitin chain polymerization; and proteolysis involved in protein catabolic process. Located in cytoplasm and nucleus. Part of proteasome complex. Is active in cytosol. Human ortholog(s) of this gene implicated in Kaufman oculocerebrofacial syndrome. Orthologous to several human genes including UBE3C (ubiquitin protein ligase E3C). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See HUL5 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (238353..241085)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene Mrf1p Neighboring gene putative glycosylphosphatidylinositol-alpha 1,2 mannosyltransferase Neighboring gene uncharacterized protein Neighboring gene putative flavin adenine dinucleotide transporter

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Hul5 ubiquitin ligase: good riddance to bad proteins. Fang NN, et al. Prion, 2012 Jul 1. PMID 22561164, Free PMC Article
    2. Ubiquitin ligase Hul5 is required for fragment-specific substrate degradation in endoplasmic reticulum-associated degradation. Kohlmann S, et al. J Biol Chem, 2008 Jun 13. PMID 18436532
    3. Generation of free ubiquitin chains is up-regulated in stress and facilitated by the HECT domain ubiquitin ligases UFD4 and HUL5. Braten O, et al. Biochem J, 2012 Jun 15. PMID 22497224
    4. CAT tails drive degradation of stalled polypeptides on and off the ribosome. Sitron CS, et al. Nat Struct Mol Biol, 2019 Jun. PMID 31133701, Free PMC Article
    5. A trio of ubiquitin ligases sequentially drives ubiquitylation and autophagic degradation of dysfunctional yeast proteasomes. Marshall RS, et al. Cell Rep, 2022 Mar 15. PMID 35294869

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Review discusses how the Hul5 protein quality control pathway may specifically target low solubility cytosolic proteins in the cell.[Review]
      Title: Hul5 ubiquitin ligase: good riddance to bad proteins.
    2. Hul5 is involved in a cytosolic protein quality control pathway that targets misfolded proteins for degradation.
      Title: Hul5 HECT ubiquitin ligase plays a major role in the ubiquitylation and turnover of cytosolic misfolded proteins.
    3. support a role for the ATPase subunits in the unfolding of proteasome substrates before insertion into the catalytic cavity and suggest a role for Hul5 in the processive degradation of proteins that are stalled on the proteasome.
      Title: The ubiquitin ligase Hul5 promotes proteasomal processivity.
    4. Hul5 is required for fragment-specific substrate degradation in endoplasmic reticulum-associated degradation
      Title: Ubiquitin ligase Hul5 is required for fragment-specific substrate degradation in endoplasmic reticulum-associated degradation.
    5. We report here a proteasome-dependent conjugating activity of Hul5 that endows proteasomes with the capacity to extend ubiquitin chains.
      Title: Ubiquitin chains are remodeled at the proteasome by opposing ubiquitin ligase and deubiquitinating activities.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin-ubiquitin ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in ERAD pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to heat IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in free ubiquitin chain polymerization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein polyubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein polyubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of proteasome complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ubiquitin-ubiquitin ligase HUL5
    NP_011374.1
    • Multiubiquitin chain assembly factor (E4); proteasome processivity factor that elongates polyUb chains on substrates, opposing Ubp6p, a branched polyubiquitin protease; required for retrograde transport of misfolded proteins during ERAD; required for ubiquitination of a subset of cytosolic misfolded proteins upon heat shock

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      238353..241085
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181006.1 → NP_011374.1  TPA: ubiquitin-ubiquitin ligase HUL5 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011374.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VU08, P53119
      UniProtKB/TrEMBL
      B5VII9, C7GPR2, C8Z8A9, N1P9N1
      Conserved Domains (1) summary
      COG5021
      Location:35 → 910
      HUL4; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53119.1

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