MCY1 putative cysteine synthase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: MCY1
Official Full Name: putative cysteine synthase
Primary source: SGD:S000003244
Locus tag: YGR012W
See related: AllianceGenome:SGD:S000003244; FungiDB:YGR012W; VEuPathDB:YGR012W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: TCD3
Summary: Predicted to enable cysteine synthase activity. Predicted to be involved in cysteine biosynthetic process from serine. Located in mitochondrial outer membrane. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See MCY1 in Genome Data Viewer

Location:: chromosome: VII

Exon count:: 1

Sequence:: Chromosome: VII; NC_001139.9 (513159..514340)

Chromosome VII - NC_001139.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables cysteine synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine synthase activity	IEA Inferred from Electronic Annotation more info
enables molecular_function	ND No biological Data available more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in cysteine biosynthetic process from serine	IBA Inferred from Biological aspect of Ancestor more info
involved_in cysteine biosynthetic process from serine	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial outer membrane	HDA more info	PubMed
located_in mitochondrial outer membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: putative cysteine synthase

NP_011526.1

EC 2.5.1.47

Putative cysteine synthase; localized to the mitochondrial outer membrane; interacts with TCD1 and TCD2, likely forming a complex

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001139.9 Reference assembly

Range

513159..514340

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001181141.1 → NP_011526.1 TPA: putative cysteine synthase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_011526.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VUE8, P53206

UniProtKB/TrEMBL

A6ZV03, B3LIK5, B5VIX1, C7GK81, C8Z8Q6, G2WEA4, N1P9U0

Conserved Domains (1) summary

cd01561
Location:54 → 372

CBS_like; This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine. Deficiency of ...