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    SLP1 Slp1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854325, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SLP1
    Official Full Name
    Slp1p
    Primary source
    SGD:S000005680
    Locus tag
    YOR154W
    See related
    AllianceGenome:SGD:S000005680; FungiDB:YOR154W; VEuPathDB:YOR154W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in protein folding in endoplasmic reticulum. Located in endoplasmic reticulum membrane. Orthologous to human SUCO (SUN domain containing ossification factor). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SLP1 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (624729..626492)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Atg40p Neighboring gene ATP-binding cassette multidrug transporter PDR5 Neighboring gene IMP 5'-nucleotidase Neighboring gene SUMO ligase NFI1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Sad1-UNC-84 homology domain in Mps3 interacts with Mps2 to connect the spindle pole body with the nuclear envelope. Jaspersen SL, et al. J Cell Biol, 2006 Aug 28. PMID 16923827, Free PMC Article
    2. Genome-wide association analysis of clinical vs. nonclinical origin provides insights into Saccharomyces cerevisiae pathogenesis. Muller LA, et al. Mol Ecol, 2011 Oct. PMID 21880084, Free PMC Article
    3. Constructing gene co-expression networks and predicting functions of unknown genes by random matrix theory. Luo F, et al. BMC Bioinformatics, 2007 Aug 14. PMID 17697349, Free PMC Article
    4. Slp1-Emp65: A Guardian Factor that Protects Folding Polypeptides from Promiscuous Degradation. Zhang S, et al. Cell, 2017 Oct 5. PMID 28919078
    5. Cdc1 removes the ethanolamine phosphate of the first mannose of GPI anchors and thereby facilitates the integration of GPI proteins into the yeast cell wall. Vazquez HM, et al. Mol Biol Cell, 2014 Nov 1. PMID 25165136, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein folding in endoplasmic reticulum HGI PubMed 
    Component Evidence Code Pubs
    located_in cell periphery HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Slp1p
    NP_014797.1
    • Glycosylated integral ER membrane hypothetical protein; forms an ER-membrane associated protein complex with Emp65p; member of the SUN-like family of proteins; genetic interactions suggest a role in folding of ER membrane proteins; required for nuclear envelope localization of Mps3p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      624729..626492
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183573.1 → NP_014797.1  TPA: Slp1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014797.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W2L1, Q12232
      UniProtKB/TrEMBL
      C7GN70, N1NVT4
      Conserved Domains (1) summary
      pfam07738
      Location:204 → 330
      Sad1_UNC; Sad1 / UNC-like C-terminal
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12232.1

    Gene LinkOut

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