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    RSC58 Rsc58p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850720, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RSC58
    Official Full Name
    Rsc58p
    Primary source
    SGD:S000004023
    Locus tag
    YLR033W
    See related
    AllianceGenome:SGD:S000004023; FungiDB:YLR033W; VEuPathDB:YLR033W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in nucleosome disassembly and transcription elongation by RNA polymerase II. Part of RSC-type complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See RSC58 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (208761..210269)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene DNA helicase RAD5 Neighboring gene putative divalent metal ion transporter SMF3 Neighboring gene mismatch repair protein MLH2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Temporal sequence and cell cycle cues in the assembly of host factors at the yeast 2 micron plasmid partitioning locus. Ma CH, et al. Nucleic Acids Res, 2013 Feb 1. PMID 23275556, Free PMC Article
    2. Genetic analysis of RSC58, which encodes a component of a yeast chromatin remodeling complex, and interacts with the transcription factor Swi6. Taneda T, et al. Mol Genet Genomics, 2004 May. PMID 15034784
    3. The haploinsufficiency profile of α-hederin suggests a caspofungin-like antifungal mode of action. Prescott TA, et al. Phytochemistry, 2014 May. PMID 24569176
    4. A yeast chemical genetics approach identifies the compound 3,4,5-trimethoxybenzyl isothiocyanate as a calcineurin inhibitor. Prescott TA, et al. FEBS Lett, 2014 Jan 31. PMID 24374339
    5. Activated RSC-nucleosome complex and persistently altered form of the nucleosome. Lorch Y, et al. Cell, 1998 Jul 10. PMID 9674424

    See all (77) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in nucleosome disassembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transcription elongation by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of RSC-type complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of RSC-type complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Rsc58p
    NP_013133.1
    • Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      208761..210269
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181920.1 → NP_013133.1  TPA: Rsc58p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013133.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VY35, Q07979
      UniProtKB/TrEMBL
      A7A0T9, B3LT05, C7GXH8, C8ZD05
      Conserved Domains (1) summary
      cl02556
      Location:39 → 122
      Bromodomain; Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q07979.1

    Gene LinkOut

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