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    PWP1 rRNA-processing protein PWP1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850893, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PWP1
    Official Full Name
    rRNA-processing protein PWP1
    Primary source
    SGD:S000004186
    Locus tag
    YLR196W
    See related
    AllianceGenome:SGD:S000004186; FungiDB:YLR196W; VEuPathDB:YLR196W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in rRNA processing. Located in cytoplasm and nucleolus. Orthologous to human PWP1 (PWP1 homolog, endonuclein). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See PWP1 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (543968..545698)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Ncw2p Neighboring gene glycylpeptide N-tetradecanoyltransferase NMT1 Neighboring gene snoRNP complex protein NOP56 Neighboring gene Pba1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Comparative analysis of the beta transducin family with identification of several new members including PWP1, a nonessential gene of Saccharomyces cerevisiae that is divergently transcribed from NMT1. Duronio RJ, et al. Proteins, 1992 May. PMID 1594577
    2. The functional landscape of mouse gene expression. Zhang W, et al. J Biol, 2004. PMID 15588312, Free PMC Article
    3. The WD40-repeat protein Pwp1p associates in vivo with 25S ribosomal chromatin in a histone H4 tail-dependent manner. Suka N, et al. Nucleic Acids Res, 2006. PMID 16855292, Free PMC Article
    4. Cloning of a cDNA encoding a novel human nuclear phosphoprotein belonging to the WD-40 family. Honoré B, et al. Gene, 1994 Dec 30. PMID 7828893
    5. Disome and Trisome Profiling Reveal Genome-wide Targets of Ribosome Quality Control. Meydan S, et al. Mol Cell, 2020 Aug 20. PMID 32615089, Free PMC Article

    See all (83) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Misfolded pre-rRNAs are stable in the absence of Nop12 but rapidly turned over when Pwp1 is not present.
      Title: Ribosome assembly factors Pwp1 and Nop12 are important for folding of 5.8S rRNA during ribosome biogenesis in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in rRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in nucleolus HDA PubMed 
    located_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    rRNA-processing protein PWP1
    NP_013297.1
    • Protein with WD-40 repeats involved in rRNA processing; associates with rDNA chromatin in H4-tail-dependent manner; associates with trans-acting ribosome biogenesis factors; similar to beta-transducin superfamily

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      543968..545698
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182083.1 → NP_013297.1  TPA: rRNA-processing protein PWP1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013297.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VYJ9, P21304
      UniProtKB/TrEMBL
      A7A186, B3RH87, C7GIS8, N1NZT2
      Conserved Domains (2) summary
      COG2319
      Location:280 → 554
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:289 → 327
      7WD40; WD40 repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P21304.1

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