BCY1 cAMP-dependent protein kinase regulatory subunit BCY1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: BCY1
Official Full Name: cAMP-dependent protein kinase regulatory subunit BCY1
Primary source: SGD:S000001295
Locus tag: YIL033C
See related: AllianceGenome:SGD:S000001295; FungiDB:YIL033C; VEuPathDB:YIL033C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: SRA1
Summary: Enables cAMP-dependent protein kinase inhibitor activity. Involved in several processes, including cellular response to glucose starvation; negative regulation of Ras protein signal transduction; and protein localization to bud neck. Located in several cellular components, including chromatin; nucleus; and plasma membrane. Human ortholog(s) of this gene implicated in congestive heart failure. Orthologous to human PRKAR2A (protein kinase cAMP-dependent type II regulatory subunit alpha) and PRKAR2B (protein kinase cAMP-dependent type II regulatory subunit beta). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See BCY1 in Genome Data Viewer

Location:: chromosome: IX

Exon count:: 1

Sequence:: Chromosome: IX; NC_001141.2 (290419..291669, complement)

Chromosome IX - NC_001141.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001141.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The crystal structure of yeast regulatory subunit reveals key evolutionary insights into Protein Kinase A oligomerization.
Title: The crystal structure of yeast regulatory subunit reveals key evolutionary insights into Protein Kinase A oligomerization.
Phenomic screen identifies a role for the yeast lysine acetyltransferase NuA4 in the control of Bcy1 subcellular localization, glycogen biosynthesis, and mitochondrial morphology.
Title: Phenomic screen identifies a role for the yeast lysine acetyltransferase NuA4 in the control of Bcy1 subcellular localization, glycogen biosynthesis, and mitochondrial morphology.
the physiological relevance of the interaction of both Ira2 and Hsp60 with Bcy1. Bcy1 interacts with Ira2 tethering PKA to the Ras complex and Hsp60 chaperone localizes PKA to mitochondria and has a role in the kinase stability.
Title: Interacting proteins of protein kinase A regulatory subunit in Saccharomyces cerevisiae.
Data found Bcy1p a key regulator in the cAMP-PKA signalling pathway down-regulating unfolded protein response.
Title: Kinetochore genes are required to fully activate secretory pathway expansion in S. cerevisiae under induced ER stress.
These data indicated that Sch9 regulated localization of Bcy1 via Zds1.
Title: Mechanisms of protein kinase Sch9 regulating Bcy1 in Saccharomyces cerevisiae.
in addition to its negative regulatory role, the R subunit of Protein Kinase C stimulates C activity via distal interactions
Title: A novel activating effect of the regulatory subunit of protein kinase A on catalytic subunit activity.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables cAMP binding	IBA Inferred from Biological aspect of Ancestor more info
enables cAMP binding	IEA Inferred from Electronic Annotation more info
enables cAMP-dependent protein kinase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables cAMP-dependent protein kinase inhibitor activity	IDA Inferred from Direct Assay more info	PubMed
enables cAMP-dependent protein kinase inhibitor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables cAMP-dependent protein kinase regulator activity	IEA Inferred from Electronic Annotation more info
enables protein kinase A catalytic subunit binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to glucose starvation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to nitrogen starvation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of Ras protein signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of Ras protein signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to bud neck	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of cytoplasmic mRNA processing body assembly	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of cAMP-dependent protein kinase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of cAMP-dependent protein kinase complex	IEA Inferred from Electronic Annotation more info
located_in chromatin	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	HDA more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	HDA more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: cAMP-dependent protein kinase regulatory subunit BCY1

NP_012231.1

Regulatory subunit of the cyclic AMP-dependent protein kinase (PKA); PKA is a component of a signaling pathway that controls a variety of cellular processes, including metabolism, cell cycle, stress response, stationary phase, and sporulation; regulator of meiotic commitment

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001141.2 Reference assembly

Range

290419..291669 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001179383.1 → NP_012231.1 TPA: cAMP-dependent protein kinase regulatory subunit BCY1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_012231.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VVP9, P07278

UniProtKB/TrEMBL

A6ZVN6, B3LTN9, C7GVW1, C8ZAL3, G2WGB3, N1P1N6

Conserved Domains (2) summary

cd12098
Location:7 → 44

DD_R_PKA_fungi; Dimerization/Docking domain of the Regulatory subunit of fungal cAMP-dependent protein kinase

cd00038
Location:184 → 282

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...