PRO2 glutamate-5-semialdehyde dehydrogenase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: PRO2
Official Full Name: glutamate-5-semialdehyde dehydrogenase
Primary source: SGD:S000005850
Locus tag: YOR323C
See related: AllianceGenome:SGD:S000005850; FungiDB:YOR323C; VEuPathDB:YOR323C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables glutamate-5-semialdehyde dehydrogenase activity. Involved in proline biosynthetic process. Located in mitochondrion. Human ortholog(s) of this gene implicated in cataract; cutis laxa (multiple); enterocele; and hereditary spastic paraplegia (multiple). Orthologous to human ALDH18A1 (aldehyde dehydrogenase 18 family member A1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See PRO2 in Genome Data Viewer

Location:: chromosome: XV

Exon count:: 1

Sequence:: Chromosome: XV; NC_001147.6 (921535..922905, complement)

Chromosome XV - NC_001147.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables NADP binding	IEA Inferred from Electronic Annotation more info
enables glutamate-5-semialdehyde dehydrogenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glutamate-5-semialdehyde dehydrogenase activity	IDA Inferred from Direct Assay more info	PubMed
enables glutamate-5-semialdehyde dehydrogenase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in L-proline biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in amino acid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in proline biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in proline biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	HDA more info	PubMed

General protein information

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Preferred Names: glutamate-5-semialdehyde dehydrogenase

NP_014968.1

EC 1.2.1.41

Cytosolic gamma-glutamyl phosphate reductase; catalyzes the second step in proline biosynthesis

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001147.6 Reference assembly

Range

921535..922905 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001183743.1 → NP_014968.1 TPA: glutamate-5-semialdehyde dehydrogenase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_014968.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W321, P54885

UniProtKB/TrEMBL

A6ZPF6, B3LJY5, C7GNU0, C8ZH74, G2WNI8, N1NW80

Conserved Domains (1) summary

TIGR00407
Location:11 → 422

proA; gamma-glutamyl phosphate reductase