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    RTT10 Rtt10p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855919, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RTT10
    Official Full Name
    Rtt10p
    Primary source
    SGD:S000006104
    Locus tag
    YPL183C
    See related
    AllianceGenome:SGD:S000006104; FungiDB:YPL183C; VEuPathDB:YPL183C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    ERE2; TRM734
    Summary
    Involved in endocytic recycling and wobble position ribose methylation. Located in endosome. Orthologous to human WDR6 (WD repeat domain 6). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See RTT10 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (199495..202536, complement)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Mrn1p Neighboring gene putative mitochondrial 54S ribosomal protein RTC6 Neighboring gene Cti6p Neighboring gene Tco89p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Different phosphoisoforms of RNA polymerase II engage the Rtt103 termination factor in a structurally analogous manner. Nemec CM, et al. Proc Natl Acad Sci U S A, 2017 May 16. PMID 28465432, Free PMC Article
    2. Structure of tRNA methyltransferase complex of Trm7 and Trm734 reveals a novel binding interface for tRNA recognition. Hirata A, et al. Nucleic Acids Res, 2019 Nov 18. PMID 31586407, Free PMC Article
    3. The conserved histone deacetylase Rpd3 and its DNA binding subunit Ume6 control dynamic transcript architecture during mitotic growth and meiotic development. Lardenois A, et al. Nucleic Acids Res, 2015 Jan. PMID 25477386, Free PMC Article
    4. Two novel WD40 domain-containing proteins, Ere1 and Ere2, function in the retromer-mediated endosomal recycling pathway. Shi Y, et al. Mol Biol Cell, 2011 Nov. PMID 21880895, Free PMC Article
    5. Chromatin-associated genes protect the yeast genome from Ty1 insertional mutagenesis. Nyswaner KM, et al. Genetics, 2008 Jan. PMID 18202368, Free PMC Article

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Trm7 interacts with distinct proteins for critical modifications of the tRNAPhe anticodon loop.
      Title: Yeast Trm7 interacts with distinct proteins for critical modifications of the tRNAPhe anticodon loop.
    2. our data indicate that a complex containing the two novel proteins, Ere1 and Ere2, mediates cargo-specific recognition by the retromer pathway. [Ere2]
      Title: Two novel WD40 domain-containing proteins, Ere1 and Ere2, function in the retromer-mediated endosomal recycling pathway.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in endocytic recycling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tRNA methylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in wobble position ribose methylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in wobble position ribose methylation IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Rtt10p
    NP_015142.1
    • WD40 domain-containing protein involved in endosomal recycling; forms a complex with Rrt2p that functions in the retromer-mediated pathway for recycling internalized cell-surface proteins; interacts with Trm7p for 2'-O-methylation of N34 of substrate tRNAs; has a role in regulation of Ty1 transposition; human ortholog is WDR6

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      199495..202536 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183997.1 → NP_015142.1  TPA: Rtt10p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015142.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W3I6, Q08924
      UniProtKB/TrEMBL
      C7GJD1, C8ZIJ5, N1NWB0
      Conserved Domains (3) summary
      COG2319
      Location:175 → 525
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:224 → 261
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:5 → 297
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q08924.1

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