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    SEC5 exocyst subunit SEC5 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851744, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SEC5
    Official Full Name
    exocyst subunit SEC5
    Primary source
    SGD:S000002573
    Locus tag
    YDR166C
    See related
    AllianceGenome:SGD:S000002573; FungiDB:YDR166C; VEuPathDB:YDR166C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in Golgi to plasma membrane transport; endoplasmic reticulum inheritance; and exocyst assembly. Located in cellular bud neck; cellular bud tip; and incipient cellular bud site. Part of exocyst. Orthologous to human EXOC2 (exocyst complex component 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SEC5 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (786306..789221, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Sec1p Neighboring gene Trm82p Neighboring gene Taf10p Neighboring gene Cdc37p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Decreased proteinase A excretion by strengthening its vacuolar sorting and weakening its constitutive secretion in Saccharomyces cerevisiae. Chen Y, et al. J Ind Microbiol Biotechnol, 2017 Jan. PMID 27866332
    2. Molecular characterization of the SEC1 gene of Saccharomyces cerevisiae: subcellular distribution of a protein required for yeast protein secretion. Egerton M, et al. Yeast, 1993 Jul. PMID 8368004
    3. Spatial regulation of the exocyst complex by Rho1 GTPase. Guo W, et al. Nat Cell Biol, 2001 Apr. PMID 11283608
    4. Exo84p is an exocyst protein essential for secretion. Guo W, et al. J Biol Chem, 1999 Aug 13. PMID 10438536
    5. A conditional sterol esterification defect in yeast having either a sec1 or sec5 mutation in the secretory pathway. Tomeo ME, et al. Yeast, 1997 Apr. PMID 9153755

    See all (93) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in Golgi to plasma membrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in Golgi to plasma membrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in Golgi to plasma membrane transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in Golgi to plasma membrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endoplasmic reticulum inheritance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in exocyst assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in exocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in exocytosis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in exocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell periphery HDA PubMed 
    located_in cellular bud neck HDA PubMed 
    located_in cellular bud neck IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cellular bud tip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of exocyst IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of exocyst IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of exocyst IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in incipient cellular bud site IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mating projection tip HDA PubMed 
    located_in prospore membrane HDA PubMed 

    General protein information

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    Preferred Names
    exocyst subunit SEC5
    NP_010450.3
    • Essential 107kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior to SNARE-mediated fusion; involved in assembly of the exocyst complex; required with Sec3p for ER inheritance where it promotes anchoring of the cortical ER at the bud tip

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      786306..789221 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180473.3 → NP_010450.3  TPA: exocyst subunit SEC5 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010450.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VSE6, P89102, Q03775, Q04128
      UniProtKB/TrEMBL
      B3LGB8, B5VG61, C7GQF3, C8Z580
      Conserved Domains (1) summary
      pfam15469
      Location:146 → 359
      Sec5; Exocyst complex component Sec5
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P89102.1

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