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    sin1 MAP kinase-interacting protein Sin1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2542972, updated on 18-Sep-2024

    Summary

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    Official Symbol
    sin1
    Official Full Name
    MAP kinase-interacting protein Sin1
    Primary source
    PomBase:SPAPYUG7.02c
    Locus tag
    SPOM_SPAPYUG7.02C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See sin1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    3
    Sequence:
    Chromosome: I; NC_003424.3 (4746022..4748427, complement)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol 3-kinase Pik3 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene WD repeat-containing protein Atg1803 Neighboring gene ncRNA Neighboring gene transcription factor TFIIE subunit Tfa1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene septin ring organizing protein Neighboring gene ncRNA Neighboring gene DNA-directed RNA polymerase II complex TFIIS subunit Rpb9 Neighboring gene delta-1-pyrroline-5-carboxylate reductase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Phosphorylation of the amino-terminus of the AGC kinase Gad8 prevents its interaction with TORC2. Du W, et al. Open Biol, 2016 Mar. PMID 26935949, Free PMC Article
    2. Modulation of TOR complex 2 signaling by the stress-activated MAPK pathway in fission yeast. Morigasaki S, et al. J Cell Sci, 2019 Oct 10. PMID 31477575
    3. Sin1: an evolutionarily conserved component of the eukaryotic SAPK pathway. Wilkinson MG, et al. EMBO J, 1999 Aug 2. PMID 10428959, Free PMC Article
    4. Fission yeast Ryh1 GTPase activates TOR Complex 2 in response to glucose. Hatano T, et al. Cell Cycle, 2015. PMID 25590601, Free PMC Article
    5. Fission yeast TOR complex 2 activates the AGC-family Gad8 kinase essential for stress resistance and cell cycle control. Ikeda K, et al. Cell Cycle, 2008 Feb 1. PMID 18235227, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables enzyme-substrate adaptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphatidylinositol-4,5-bisphosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in TORC2 signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in TORC2 signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in p38MAPK cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of G2/M transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of conjugation with cellular fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of TORC2 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of TORC2 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol HDA PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    MAP kinase-interacting protein Sin1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      4746022..4748427 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001020130.3 → NP_594703.1  MAP kinase-interacting protein Sin1 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_594703.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q9P7Y9, Q9Y7F5
      Conserved Domains (3) summary
      pfam05422
      Location:41 → 206
      SIN1; Stress-activated map kinase interacting protein 1 (SIN1)
      pfam16978
      Location:255 → 392
      CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain
      pfam16979
      Location:557 → 658
      SIN1_PH; SAPK-interacting protein 1 (Sin1), Pleckstrin-homology
    Nucleotide Protein
    Heading Accession and Version

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