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    LMO1 Lmo1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850653, updated on 9-Dec-2024

    Summary

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    Official Symbol
    LMO1
    Official Full Name
    Lmo1p
    Primary source
    SGD:S000003930
    Locus tag
    YLL007C
    See related
    AllianceGenome:SGD:S000003930; FungiDB:YLL007C; VEuPathDB:YLL007C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in autophagy of mitochondrion and intracellular signal transduction. Located in mitochondrion and plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See LMO1 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (134302..136299, complement)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene copper metallochaperone COX17 Neighboring gene putative ATP-dependent RNA helicase Neighboring gene uncharacterized protein Neighboring gene ERMES complex subunit MMM1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of Dck1 and Lmo1 as upstream regulators of the small GTPase Rho5 in Saccharomyces cerevisiae. Schmitz HP, et al. Mol Microbiol, 2015 Apr. PMID 25598154
    2. The Small Yeast GTPase Rho5 and Its Dimeric GEF Dck1/Lmo1 Respond to Glucose Starvation. Schmitz HP, et al. Int J Mol Sci, 2018 Jul 26. PMID 30049968, Free PMC Article
    3. Protective role of the HOG pathway against the growth defect caused by impaired biosynthesis of complex sphingolipids in yeast Saccharomyces cerevisiae. Yamaguchi Y, et al. Mol Microbiol, 2018 Feb. PMID 29215176
    4. Alterations in DNA replication and histone levels promote histone gene amplification in Saccharomyces cerevisiae. Libuda DE, et al. Genetics, 2010 Apr. PMID 20139344, Free PMC Article
    5. INA complex liaises the F(1)F(o)-ATP synthase membrane motor modules. Naumenko N, et al. Nat Commun, 2017 Nov 1. PMID 29093463, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in autophagy of mitochondrion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular signal transduction IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in intracellular signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Lmo1p
    NP_013094.1
    • Homolog of mammalian ELMO (Engulfment and celL MOtility); upstream component for regulation through the small GTPase Rho5p; may form a complex with Dck1p that acts as a GEF for Rho5p; cytoplasmic protein that relocates to mitochondria under oxidative stress; implicated in mitophagy; not an essential protein

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      134302..136299 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181827.1 → NP_013094.1  TPA: Lmo1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013094.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VXZ5, E9PAG4, Q07799
      UniProtKB/TrEMBL
      A7A0P9, G2WII8
      Conserved Domains (1) summary
      cl17171
      Location:450 → 594
      PH-like; Pleckstrin homology-like domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q07799.1

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