SRP54 RNA-binding signal recognition particle subunit SRP54 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: SRP54
Official Full Name: RNA-binding signal recognition particle subunit SRP54
Primary source: SGD:S000006292
Locus tag: YPR088C
See related: AllianceGenome:SGD:S000006292; FungiDB:YPR088C; VEuPathDB:YPR088C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: SRH1
Summary: Enables 7S RNA binding activity. Involved in SRP-dependent cotranslational protein targeting to membrane. Located in endoplasmic reticulum. Part of signal recognition particle, endoplasmic reticulum targeting. Used to study severe congenital neutropenia 8. Human ortholog(s) of this gene implicated in severe congenital neutropenia 8. Orthologous to human SRP54 (signal recognition particle 54). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See SRP54 in Genome Data Viewer

Location:: chromosome: XVI

Exon count:: 1

Sequence:: Chromosome: XVI; NC_001148.4 (711403..713028, complement)

Chromosome XVI - NC_001148.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables 7S RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables 7S RNA binding	IDA Inferred from Direct Assay more info	PubMed
enables 7S RNA binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activator activity	IEA Inferred from Electronic Annotation more info
contributes_to GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables endoplasmic reticulum signal peptide binding	IBA Inferred from Biological aspect of Ancestor more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in SRP-dependent cotranslational protein targeting to membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in SRP-dependent cotranslational protein targeting to membrane	IEA Inferred from Electronic Annotation more info
involved_in SRP-dependent cotranslational protein targeting to membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in SRP-dependent cotranslational protein targeting to membrane, translocation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	HDA more info	PubMed
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
part_of signal recognition particle	IEA Inferred from Electronic Annotation more info
part_of signal recognition particle, endoplasmic reticulum targeting	IBA Inferred from Biological aspect of Ancestor more info
part_of signal recognition particle, endoplasmic reticulum targeting	IDA Inferred from Direct Assay more info	PubMed
part_of signal recognition particle, endoplasmic reticulum targeting	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: RNA-binding signal recognition particle subunit SRP54

NP_015413.1

EC 3.6.5.4

Signal recognition particle (SRP) subunit (homolog of mammalian SRP54); contains the signal sequence-binding activity of SRP, interacts with the SRP RNA, and mediates binding of SRP to signal receptor; contains GTPase domain

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001148.4 Reference assembly

Range

711403..713028 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001184185.1 → NP_015413.1 TPA: RNA-binding signal recognition particle subunit SRP54 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_015413.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W489, P20424

UniProtKB/TrEMBL

A6ZWX2, B5VTN4, C7GPT0, C8ZJB2, G2WPQ7, N1NW32

Conserved Domains (2) summary

TIGR01425
Location:2 → 436

SRP54_euk; signal recognition particle protein SRP54

pfam07271
Location:431 → 484

Cytadhesin_P30; Cytadhesin P30/P32