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    DDP1 polyphosphatase DDP1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854334, updated on 9-Dec-2024

    Summary

    Official Symbol
    DDP1
    Official Full Name
    polyphosphatase DDP1
    Primary source
    SGD:S000005689
    Locus tag
    YOR163W
    See related
    AllianceGenome:SGD:S000005689; FungiDB:YOR163W; VEuPathDB:YOR163W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables phosphodiesterase decapping endonuclease activity and pyrophosphatase activity. Involved in diadenosine polyphosphate catabolic process and polyphosphate catabolic process. Located in cytoplasm and nucleus. Orthologous to several human genes including NUDT10 (nudix hydrolase 10); NUDT3 (nudix hydrolase 3); and NUDT4 (nudix hydrolase 4). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See DDP1 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (642741..643307)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Yrr1p Neighboring gene Get4p Neighboring gene dynamin-like GTPase SEY1

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables bis(5'-adenosyl)-hexaphosphatase activity  
    enables bis(5'-adenosyl)-hexaphosphatase activity PubMed 
    enables bis(5'-adenosyl)-hexaphosphatase activity  
    enables bis(5'-adenosyl)-pentaphosphatase activity  
    enables bis(5'-adenosyl)-pentaphosphatase activity PubMed 
    enables diphosphoinositol-polyphosphate diphosphatase activity  
    enables diphosphoinositol-polyphosphate diphosphatase activity PubMed 
    enables diphosphoinositol-polyphosphate diphosphatase activity  
    enables endopolyphosphatase activity  
    enables endopolyphosphatase activity PubMed 
    enables endopolyphosphatase activity  
    enables hydrolase activity  
    enables metal ion binding  
    enables phosphodiesterase decapping endonuclease activity PubMed 
    enables pyrophosphatase activity  
    Component Evidence Code Pubs
    located_in cytoplasm PubMed 
    is_active_in cytoplasm  
    located_in cytoplasm  
    located_in nucleus PubMed 
    is_active_in nucleus  
    located_in nucleus  

    General protein information

    Preferred Names
    polyphosphatase DDP1
    NP_014806.1
    • Diadenosine and diphosphoinositol polyphosphate phosphatase; hydrolyzes diphosphorylated inositol polyphosphates and diadenosine polyphosphates; high specificity for diadenosine hexa- and pentaphosphates; contains endopolyphosphatase activity with a high affinity for polyphosphates, an activity also observed for its human DIPP homologs; possesses mRNA decapping activity; nudix hydrolase family member; protein abundance increases in response to DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      642741..643307
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183582.1NP_014806.1  TPA: polyphosphatase DDP1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014806.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W2M1, Q99321
      UniProtKB/TrEMBL
      A6ZP08, B3LJJ6, C7GN61, C8ZGS4, G2WN36, N1NWP4
      Conserved Domains (1) summary
      cd04666
      Location:33174
      Nudix_Hydrolase_9; Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly ...
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