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    cbf12 DNA-binding transcription factor, CBF1/Su(H)/LAG-1 family Cbf12 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2539119, updated on 18-Sep-2024

    Summary

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    Official Symbol
    cbf12
    Official Full Name
    DNA-binding transcription factor, CBF1/Su(H)/LAG-1 family Cbf12
    Primary source
    PomBase:SPCC1223.13
    Locus tag
    SPOM_SPCC1223.13
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See cbf12 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    1
    Sequence:
    Chromosome: III; NC_003421.2 (1871367..1875842)

    Chromosome III - NC_003421.2Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene serine/threonine protein phosphatase PP2C catalytic subunit Ptc2 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene GPI-anchored protein Meu10 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene chorismate synthase Neighboring gene calcium/calmodulin-dependent (CaMKK) protein kinase Ssp1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003421.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Fission yeast CSL proteins function as transcription factors. Oravcová M, et al. PLoS One, 2013. PMID 23555033, Free PMC Article
    2. N-termini of fungal CSL transcription factors are disordered, enriched in regulatory motifs and inhibit DNA binding in fission yeast. Převorovský M, et al. PLoS One, 2011. PMID 21858190, Free PMC Article
    3. Cbf11 and Cbf12, the fission yeast CSL proteins, play opposing roles in cell adhesion and coordination of cell and nuclear division. Prevorovský M, et al. Exp Cell Res, 2009 May 1. PMID 19101542
    4. Fission Yeast CSL Transcription Factors: Mapping Their Target Genes and Biological Roles. Převorovský M, et al. PLoS One, 2015. PMID 26366556, Free PMC Article
    5. Conserved and Diverged Functions of the Calcineurin-Activated Prz1 Transcription Factor in Fission Yeast. Chatfield-Reed K, et al. Genetics, 2016 Apr. PMID 26896331, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results show that Cbf11 and Cbf12 bind to an overlapping set of target genes, including those with important roles in cell cycle regulation.
      Title: Fission Yeast CSL Transcription Factors: Mapping Their Target Genes and Biological Roles.
    2. Studies indicate that the Cbf11 and Cbf12 CSL paralogs play antagonistic roles in cell adhesion and the coordination of cell and nuclear division.
      Title: N-termini of fungal CSL transcription factors are disordered, enriched in regulatory motifs and inhibit DNA binding in fission yeast.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of flocculation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DNA-binding transcription factor, CBF1/Su(H)/LAG-1 family Cbf12

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003421.2 Reference assembly

      Range
      1871367..1875842
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001023349.3 → NP_588358.1  DNA-binding transcription factor, CBF1/Su(H)/LAG-1 family Cbf12 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_588358.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O74412
      Conserved Domains (2) summary
      pfam09270
      Location:631 → 825
      BTD; Beta-trefoil DNA-binding domain
      pfam09271
      Location:473 → 629
      LAG1-DNAbind; LAG1, DNA binding
    Nucleotide Protein
    Heading Accession and Version

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