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    ATG23 Atg23p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851151, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ATG23
    Official Full Name
    Atg23p
    Primary source
    SGD:S000004423
    Locus tag
    YLR431C
    See related
    AllianceGenome:SGD:S000004423; FungiDB:YLR431C; VEuPathDB:YLR431C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    CVT23
    Summary
    Involved in cytoplasm to vacuole targeting by the Cvt pathway; macroautophagy; and positive regulation of macroautophagy. Located in phagophore assembly site. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ATG23 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (1000342..1001703, complement)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Crn1p Neighboring gene DNA/RNA helicase SEN1 Neighboring gene IMP dehydrogenase IMD3 Neighboring gene calcineurin catalytic subunit A

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Atg23 is essential for the cytoplasm to vacuole targeting pathway and efficient autophagy but not pexophagy. Tucker KA, et al. J Biol Chem, 2003 Nov 28. PMID 14504273, Free PMC Article
    2. ATG23, a novel gene required for maturation of proaminopeptidase I, but not for autophagy. Meiling-Wesse K, et al. FEMS Yeast Res, 2004 Jan. PMID 14734026
    3. Dimerization-dependent membrane tethering by Atg23 is essential for yeast autophagy. Hawkins WD, et al. Cell Rep, 2022 Apr 19. PMID 35443167, Free PMC Article
    4. A cycling protein complex required for selective autophagy. Legakis JE, et al. Autophagy, 2007 Sep-Oct. PMID 17426440
    5. Phosphorylation of Atg9 regulates movement to the phagophore assembly site and the rate of autophagosome formation. Feng Y, et al. Autophagy, 2016. PMID 27050455, Free PMC Article

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TOR-mediated Ypt1 phosphorylation regulates autophagy initiation complex assembly.
      Title: TOR-mediated Ypt1 phosphorylation regulates autophagy initiation complex assembly.
    2. Overexpression of Atg23 inhibits Atg9 trafficking to the phagophore assembly site.
      Title: Atg23 and Atg27 act at the early stages of Atg9 trafficking in S. cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in autophagy IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cytoplasm to vacuole targeting by the Cvt pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nucleophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of macroautophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to phagophore assembly site IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in phagophore assembly site IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in phagophore assembly site membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Atg23p
    NP_013535.1
    • Peripheral membrane protein required for autophagy and CVT; required for cytoplasm-to-vacuole targeting (Cvt) pathway and efficient macroautophagy; cycles between the phagophore assembly site (PAS) and non-PAS locations; forms a complex with Atg9p and Atg27p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      1000342..1001703 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182319.1 → NP_013535.1  TPA: Atg23p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013535.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VZ66, Q06671
      UniProtKB/TrEMBL
      B3RHU0, B5VNW9, N1P089
      Conserved Domains (1) summary
      pfam12128
      Location:149 → 329
      DUF3584; Protein of unknown function (DUF3584)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q06671.1

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