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    cdc28 ATP-dependent RNA helicase Cdc28 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2540707, updated on 14-Nov-2024

    Summary

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    Official Symbol
    cdc28
    Official Full Name
    ATP-dependent RNA helicase Cdc28
    Primary source
    PomBase:SPBC19C2.01
    Locus tag
    SPOM_SPBC19C2.01
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    prp8
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    Genomic context

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    See cdc28 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_003423.3 (1670425..1673825)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ataxin-2-like protein Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene DNA methyltransferase Neighboring gene ncRNA Neighboring gene DNA-directed RNA polymerase subunit Rpc10

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A connection between pre-mRNA splicing and the cell cycle in fission yeast: cdc28+ is allelic with prp8+ and encodes an RNA-dependent ATPase/helicase. Lundgren K, et al. Mol Biol Cell, 1996 Jul. PMID 8862522, Free PMC Article
    2. Early splicing functions of fission yeast Prp16 and its unexpected requirement for gene Silencing is governed by intronic features. Vijayakumari D, et al. RNA Biol, 2019 Jun. PMID 30810475, Free PMC Article
    3. Regulation of Cdc2p and Cdc13p is required for cell cycle arrest induced by defective RNA splicing in fission yeast. Shimada M, et al. J Biol Chem, 2005 Sep 23. PMID 16049013
    4. Ubiquitin-like protein Hub1 is required for pre-mRNA splicing and localization of an essential splicing factor in fission yeast. Wilkinson CR, et al. Curr Biol, 2004 Dec 29. PMID 15620657
    5. Characterization of the ptr5+ gene involved in nuclear mRNA export in fission yeast. Watanabe N, et al. Biochem Biophys Res Commun, 2012 Feb 3. PMID 22240020

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA helicase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in generation of catalytic spliceosome for first transesterification step ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of U2-type catalytic step 1 spliceosome IC
    Inferred by Curator
    more info
    		  
    part_of spliceosomal complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ATP-dependent RNA helicase Cdc28

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      1670425..1673825
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001021581.4 → NP_595686.2  ATP-dependent RNA helicase Cdc28 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_595686.2

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q10752, Q9URU1, Q9USV9, Q9UUD7
      Conserved Domains (6) summary
      smart00847
      Location:817 → 901
      HA2; Helicase associated domain (HA2) Add an annotation
      COG1643
      Location:389 → 1033
      HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
      cd00046
      Location:435 → 574
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      pfam00271
      Location:615 → 749
      Helicase_C; Helicase conserved C-terminal domain
      pfam07717
      Location:923 → 1037
      OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold
      cl23720
      Location:226 → 294
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    Nucleotide Protein
    Heading Accession and Version

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