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    XPT1 xanthine phosphoribosyltransferase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853597, updated on 9-Dec-2024

    Summary

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    Official Symbol
    XPT1
    Official Full Name
    xanthine phosphoribosyltransferase
    Primary source
    SGD:S000003894
    Locus tag
    YJR133W
    See related
    AllianceGenome:SGD:S000003894; FungiDB:YJR133W; VEuPathDB:YJR133W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables hypoxanthine phosphoribosyltransferase activity and xanthine phosphoribosyltransferase activity. Involved in XMP salvage and hypoxanthine metabolic process. Located in cytoplasm. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See XPT1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (672991..673620)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene mannosyl-oligosaccharide 1,2-alpha-mannosidase Neighboring gene Nmd5p Neighboring gene Sgm1p Neighboring gene Mcm22p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Isolation and characterization of the Saccharomyces cerevisiae XPT1 gene encoding xanthine phosphoribosyl transferase. Guetsova ML, et al. J Bacteriol, 1999 May. PMID 10217799, Free PMC Article
    2. Control of ATP homeostasis during the respiro-fermentative transition in yeast. Walther T, et al. Mol Syst Biol, 2010. PMID 20087341, Free PMC Article
    3. Genetic investigation of purine nucleotide imbalance in Saccharomyces cerevisiae. Saint-Marc C, et al. Curr Genet, 2020 Dec. PMID 32780163
    4. Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X. Galibert F, et al. EMBO J, 1996 May 1. PMID 8641269, Free PMC Article
    5. Genome-wide analysis to identify pathways affecting telomere-initiated senescence in budding yeast. Chang HY, et al. G3 (Bethesda), 2011 Aug. PMID 22384331, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hypoxanthine phosphoribosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hypoxanthine phosphoribosyltransferase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables xanthine phosphoribosyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in GMP salvage IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in IMP salvage IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in XMP salvage IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in XMP salvage IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in hypoxanthine metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in hypoxanthine metabolic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in purine nucleotide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    xanthine phosphoribosyltransferase
    NP_012667.1
    • Xanthine-guanine phosphoribosyl transferase; required for xanthine utilization and for optimal utilization of guanine

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      672991..673620
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181791.1 → NP_012667.1  TPA: xanthine phosphoribosyltransferase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012667.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VWV1, P47165
      UniProtKB/TrEMBL
      A6ZQ88, B3LQL5, C7GM80, C8ZBT1, G2WHD5, N1P1A8
      Conserved Domains (1) summary
      COG2236
      Location:3 → 205
      Hpt1; Hypoxanthine phosphoribosyltransferase [Coenzyme transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P47165.1

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