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    rad60 DNA repair protein, SUMO-related Rad60 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2540802, updated on 18-Sep-2024

    Summary

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    Official Symbol
    rad60
    Official Full Name
    DNA repair protein, SUMO-related Rad60
    Primary source
    PomBase:SPBC1921.02
    Locus tag
    SPOM_SPBC1921.02
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See rad60 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    2
    Sequence:
    Chromosome: II; NC_003423.3 (2406820..2408273)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Tor complex Tor2-interacting protein 1 Neighboring gene ncRNA Neighboring gene 60S ribosomal protein eL33 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene nucleoporin Mex67 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterisation of the SUMO-like domains of Schizosaccharomyces pombe Rad60. Boyd LK, et al. PLoS One, 2010 Sep 27. PMID 20885950, Free PMC Article
    2. Schizosaccharomyces pombe Cds1Chk2 regulates homologous recombination at stalled replication forks through the phosphorylation of recombination protein Rad60. Miyabe I, et al. J Cell Sci, 2009 Oct 15. PMID 19755492, Free PMC Article
    3. Molecular mimicry of SUMO promotes DNA repair. Prudden J, et al. Nat Struct Mol Biol, 2009 May. PMID 19363481, Free PMC Article
    4. The Schizosaccharomyces pombe rad60 gene is essential for repairing double-strand DNA breaks spontaneously occurring during replication and induced by DNA-damaging agents. Morishita T, et al. Mol Cell Biol, 2002 May. PMID 11971984, Free PMC Article
    5. SUMO-binding motifs mediate the Rad60-dependent response to replicative stress and self-association. Raffa GD, et al. J Biol Chem, 2006 Sep 22. PMID 16880212

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These results suggest that Rhp51 and Rad60 are required for the restoration of a stalled or collapsed replication fork after release from the arrest of DNA replication [Rhb51][Rad60]
      Title: Rhp51-dependent recombination intermediates that do not generate checkpoint signal are accumulated in Schizosaccharomyces pombe rad60 and smc5/6 mutants after release from replication arrest.
    2. role in protecting genome stability against spontaneous Top1-mediated DNA damage
      Title: SUMO-targeted ubiquitin ligase, Rad60, and Nse2 SUMO ligase suppress spontaneous Top1-mediated DNA damage and genome instability.
    3. SUMO-like domains 1 of Rad60 is essential for viability, while SUMO-like domains 2 is not.
      Title: Characterisation of the SUMO-like domains of Schizosaccharomyces pombe Rad60.
    4. Rad60 phosphorylation is required to regulate homologous recombination at stalled replication forks, probably by regulating Smc5/6.
      Title: Schizosaccharomyces pombe Cds1Chk2 regulates homologous recombination at stalled replication forks through the phosphorylation of recombination protein Rad60.
    5. results provide a mechanistic basis for the near-synonymous roles of Rad60 and SUMO in survival of genotoxic stress and suggest unprecedented DNA-damage-response functions for SLDs in regulating sumoylation
      Title: Molecular mimicry of SUMO promotes DNA repair.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables SUMO ligase regulator activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in double-strand break repair via homologous recombination IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in replication fork processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DNA repair protein, SUMO-related Rad60

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      2406820..2408273
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001021903.3 → NP_595995.1  DNA repair protein, SUMO-related Rad60 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_595995.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q9USX3
      Conserved Domains (2) summary
      pfam11976
      Location:334 → 405
      Rad60-SLD; Ubiquitin-2 like Rad60 SUMO-like
      cl00155
      Location:242 → 288
      UBQ; Ubiquitin-like proteins
    Nucleotide Protein
    Heading Accession and Version

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