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    dcp1 mRNA-decapping complex regulatory subunit Dcp1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2541033, updated on 18-Sep-2024

    Summary

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    Official Symbol
    dcp1
    Official Full Name
    mRNA-decapping complex regulatory subunit Dcp1
    Primary source
    PomBase:SPBC3B9.21
    Locus tag
    SPOM_SPBC3B9.21
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See dcp1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    2
    Sequence:
    Chromosome: II; NC_003423.3 (3996517..3997467)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene signal recognition particle receptor alpha subunit Srp101 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene methyltransferase Neighboring gene protein TIM chaperone Neighboring gene autophagy-associated protein Atg3 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A synergistic network of interactions promotes the formation of in vitro processing bodies and protects mRNA against decapping. Schütz S, et al. Nucleic Acids Res, 2017 Jun 20. PMID 28472520, Free PMC Article
    2. Interdomain dynamics and coactivation of the mRNA decapping enzyme Dcp2 are mediated by a gatekeeper tryptophan. Floor SN, et al. Proc Natl Acad Sci U S A, 2012 Feb 21. PMID 22323607, Free PMC Article
    3. Structural basis of dcp2 recognition and activation by dcp1. She M, et al. Mol Cell, 2008 Feb 15. PMID 18280239, Free PMC Article
    4. Biomolecular condensates amplify mRNA decapping by biasing enzyme conformation. Tibble RW, et al. Nat Chem Biol, 2021 May. PMID 33767388, Free PMC Article
    5. Changes in conformational equilibria regulate the activity of the Dcp2 decapping enzyme. Wurm JP, et al. Proc Natl Acad Sci U S A, 2017 Jun 6. PMID 28533364, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Biomolecular condensates amplify mRNA decapping by biasing enzyme conformation.
      Title: Biomolecular condensates amplify mRNA decapping by biasing enzyme conformation.
    2. This study reports a 1.6-A-resolution crystal structure of the Schizosaccharomyces pombe Dcp2-Dcp1 heterodimer in an unprecedented conformation that is tied together by an intrinsically disordered peptide from Edc1.
      Title: Structure of the Dcp2-Dcp1 mRNA-decapping complex in the activated conformation.
    3. Here is presented a 2.6-A-resolution crystal structure of a heterotrimer of fission yeast Dcp2, its essential activator Dcp1 and the human NMD cofactor PNRC2, in complex with a tight-binding cap analog.
      Title: Structural basis of mRNA-cap recognition by Dcp1-Dcp2.
    4. Edc3 & Scd6 stimulate decapping in vitro, presumably by preventing the Dcp1:Dcp2 complex from adopting an inactive conformation. Protein interactions via LSm & HLM domains were identified.
      Title: The structural basis of Edc3- and Scd6-mediated activation of the Dcp1:Dcp2 mRNA decapping complex.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    contributes_to RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mRNA phosphatase activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in deadenylation-dependent decapping of nuclear-transcribed mRNA IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA methylguanosine-cap decapping IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in nuclear-transcribed mRNA catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in P-body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of RNA decapping complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasmic stress granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol HDA PubMed 
    is_active_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    mRNA-decapping complex regulatory subunit Dcp1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      3996517..3997467
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001022584.3 → NP_596662.1  mRNA-decapping complex regulatory subunit Dcp1 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_596662.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q9P805
      Conserved Domains (1) summary
      cd09804
      Location:6 → 125
      Dcp1; mRNA decapping enzyme 1 (Dcp1)
    Nucleotide Protein
    Heading Accession and Version

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