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    AHC1 Ahc1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854188, updated on 9-Dec-2024

    Summary

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    Official Symbol
    AHC1
    Official Full Name
    Ahc1p
    Primary source
    SGD:S000005549
    Locus tag
    YOR023C
    See related
    AllianceGenome:SGD:S000005549; FungiDB:YOR023C; VEuPathDB:YOR023C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Contributes to histone acetyltransferase activity. Involved in replication-born double-strand break repair via sister chromatid exchange. Part of ADA complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See AHC1 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (376012..377712, complement)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene protein-arginine N-methyltransferase SFM1 Neighboring gene putative carboxylic ester hydrolase Neighboring gene NAD-dependent histone deacetylase HST3 Neighboring gene Bub3p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The ADA complex is a distinct histone acetyltransferase complex in Saccharomyces cerevisiae. Eberharter A, et al. Mol Cell Biol, 1999 Oct. PMID 10490601, Free PMC Article
    2. Components of the SAGA histone acetyltransferase complex are required for repressed transcription of ARG1 in rich medium. Ricci AR, et al. Mol Cell Biol, 2002 Jun. PMID 12024017, Free PMC Article
    3. N-terminal domain of nuclear IL-1α shows structural similarity to the C-terminal domain of Snf1 and binds to the HAT/core module of the SAGA complex. Zamostna B, et al. PLoS One, 2012. PMID 22879895, Free PMC Article
    4. TopBP1/Dpb11 binds DNA anaphase bridges to prevent genome instability. Germann SM, et al. J Cell Biol, 2014 Jan 6. PMID 24379413, Free PMC Article
    5. The Aurora-B-dependent NoCut checkpoint prevents damage of anaphase bridges after DNA replication stress. Amaral N, et al. Nat Cell Biol, 2016 May. PMID 27111841

    See all (55) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Chromatin regulator Ahc1p co-regulates nitrogen metabolism via interactions with multiple transcription factors in Saccharomyces cerevisiae.
      Title: Chromatin regulator Ahc1p co-regulates nitrogen metabolism via interactions with multiple transcription factors in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    contributes_to histone acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in replication-born double-strand break repair via sister chromatid exchange IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of ADA complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Ahc1p
    NP_014666.1
    • Subunit of the Ada histone acetyltransferase complex; required for structural integrity of the complex; Ahc2p and Ahc1p are unique to the ADA complex and not shared with the related SAGA and SLIK complexes; Ahc2p may tether Ahc1p to the complex

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      376012..377712 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183442.1 → NP_014666.1  TPA: Ahc1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014666.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W290, Q12433
      UniProtKB/TrEMBL
      C7GLF4, G2WMQ5
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12433.1

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