U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    top1 DNA topoisomerase I [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2540032, updated on 18-Sep-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    top1
    Official Full Name
    DNA topoisomerase I
    Primary source
    PomBase:SPBC1703.14c
    Locus tag
    SPOM_SPBC1703.14C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See top1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    3
    Sequence:
    Chromosome: II; NC_003423.3 (2941734..2944596, complement)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene tRNA-Pro Neighboring gene inorganic phosphate transporter Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene HOPS/CORVET complex subunit, vacuolar sorting protein Vps33 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Topoisomerase 1 facilitates nucleosome reassembly at stress genes during recovery. Vega M, et al. Nucleic Acids Res, 2023 Dec 11. PMID 37956308, Free PMC Article
    2. Topoisomerase I regulates open chromatin and controls gene expression in vivo. Durand-Dubief M, et al. EMBO J, 2010 Jul 7. PMID 20526281, Free PMC Article
    3. Mapping of the active site tyrosine of eukaryotic DNA topoisomerase I. Eng WK, et al. J Biol Chem, 1989 Aug 15. PMID 2547758
    4. Cloning and sequencing of Schizosaccharomyces pombe DNA topoisomerase I gene, and effect of gene disruption. Uemura T, et al. Nucleic Acids Res, 1987 Dec 10. PMID 2827111, Free PMC Article
    5. Deficiency in both type I and type II DNA topoisomerase activities differentially affect rRNA and ribosomal protein synthesis in Schizosaccharomyces pombe. Yamagishi M, et al. Curr Genet, 1988 Apr. PMID 2839305

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Topoisomerase 1 facilitates nucleosome reassembly at stress genes during recovery.
      Title: Topoisomerase 1 facilitates nucleosome reassembly at stress genes during recovery.
    2. SUMOylation and SUMO-dependent ubiquitylation by the Pli1-Slx8 axis contribute in different ways to maintain genome stability
      Title: Slx8 removes Pli1-dependent protein-SUMO conjugates including SUMOylated topoisomerase I to promote genome stability.
    3. Topoisomerase I activity is directly required for efficient nucleosome disassembly at gene promoter regions.
      Title: Topoisomerase I regulates open chromatin and controls gene expression in vivo.
    4. Schizosaccharomyces pombe Rad32(Mre11) nuclease activity is involved in the removal of both Top2 from 5' DNA ends as well as Top1 from 3' ends in vivo and a ctp1(CtIP) deletion is defective for Top2 removal but overproficient for Top1 removal.
      Title: Distinct requirements for the Rad32(Mre11) nuclease and Ctp1(CtIP) in the removal of covalently bound topoisomerase I and II from DNA.
    Submit: New GeneRIF Correction

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA topoisomerase type I (single strand cut, ATP-independent) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA topoisomerase type I (single strand cut, ATP-independent) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA topoisomerase type I (single strand cut, ATP-independent) activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA topological change IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA topological change IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chromosome segregation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic chromosome condensation ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT involved_in replication fork arrest at mating type locus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in chromatin NAS
    Non-traceable Author Statement
    more info
    		  
    is_active_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleolus HDA PubMed 
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus HDA PubMed 
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    DNA topoisomerase I

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      2941734..2944596 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001022128.3 → NP_596209.1  DNA topoisomerase I [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_596209.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P07799, Q9P7V7
      Conserved Domains (4) summary
      smart00435
      Location:339 → 787
      TOPEUc; DNA Topoisomerase I (eukaryota)
      pfam01028
      Location:412 → 608
      Topoisom_I; Eukaryotic DNA topoisomerase I, catalytic core
      pfam02919
      Location:193 → 408
      Topoisom_I_N; Eukaryotic DNA topoisomerase I, DNA binding fragment
      pfam14370
      Location:745 → 812
      Topo_C_assoc; C-terminal topoisomerase domain
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.