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    ssn6 transcriptional corepressor Ssn6 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2540656, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ssn6
    Official Full Name
    transcriptional corepressor Ssn6
    Primary source
    PomBase:SPBC23E6.09
    Locus tag
    SPOM_SPBC23E6.09
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See ssn6 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_003423.3 (3862300..3867052)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene protein sat1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene methylthioribose-1-phosphate isomerase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Individual subunits of the Ssn6-Tup11/12 corepressor are selectively required for repression of different target genes. Fagerström-Billai F, et al. Mol Cell Biol, 2007 Feb. PMID 17101775, Free PMC Article
    2. Functional comparison of the Tup11 and Tup12 transcriptional corepressors in fission yeast. Fagerström-Billai F, et al. Mol Cell Biol, 2005 Jan. PMID 15632072, Free PMC Article
    3. Iron homeostasis regulates facultative heterochromatin assembly in adaptive genome control. Gallagher PS, et al. Nat Struct Mol Biol, 2018 May. PMID 29686279, Free PMC Article
    4. The LAMMER kinase homolog, Lkh1, regulates Tup transcriptional repressors through phosphorylation in Schizosaccharomyces pombe. Kang WH, et al. J Biol Chem, 2010 Apr 30. PMID 20200159, Free PMC Article
    5. Predicting the fission yeast protein interaction network. Pancaldi V, et al. G3 (Bethesda), 2012 Apr. PMID 22540037, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ssn6, Tup11, and Tup12 are preferentially found at genomic locations at which histones are deacetylated, primarily by the Clr6 class I histone deacetylases.
      Title: Individual subunits of the Ssn6-Tup11/12 corepressor are selectively required for repression of different target genes.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chromatin DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription corepressor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Cyc8(Ssn6)-Tup1 general repressor complex EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus HDA PubMed 
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of transcription repressor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    transcriptional corepressor Ssn6

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      3862300..3867052
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001022530.3 → NP_596609.1  transcriptional corepressor Ssn6 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_596609.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O60184, Q9USA6
      Conserved Domains (7) summary
      smart00028
      Location:513 → 545
      TPR; Tetratricopeptide repeats
      COG0457
      Location:346 → 679
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:584 → 612
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:621 → 649
      TPR_1; Tetratricopeptide repeat
      pfam10243
      Location:841 → 1097
      MIP-T3; Microtubule-binding protein MIP-T3
      pfam13414
      Location:546 → 611
      TPR_11; TPR repeat
      pfam13431
      Location:390 → 421
      TPR_17; Tetratricopeptide repeat
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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