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    fml1 ATP-dependent 3' to 5' DNA helicase [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2543668, updated on 14-Nov-2024

    Summary

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    Official Symbol
    fml1
    Official Full Name
    ATP-dependent 3' to 5' DNA helicase
    Primary source
    PomBase:SPAC9.05
    Locus tag
    SPOM_SPAC9.05
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    mfh1
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    Genomic context

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    See fml1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    3
    Sequence:
    Chromosome: I; NC_003424.3 (1470834..1476275)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene retrotransposable element/transposon Tf2-type Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene 5'-methylthioribulose-1-phosphate dehydratase Neighboring gene GTPase Rbg1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene steroid reductase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The FANCM ortholog Fml1 promotes recombination at stalled replication forks and limits crossing over during DNA double-strand break repair. Sun W, et al. Mol Cell, 2008 Oct 10. PMID 18851838, Free PMC Article
    2. The ATPase activity of Fml1 is essential for its roles in homologous recombination and DNA repair. Nandi S, et al. Nucleic Acids Res, 2012 Oct. PMID 22844101, Free PMC Article
    3. The Fml1-MHF complex suppresses inter-fork strand annealing in fission yeast. Wong IN, et al. Elife, 2019 Dec 19. PMID 31855181, Free PMC Article
    4. The fission yeast FANCM ortholog directs non-crossover recombination during meiosis. Lorenz A, et al. Science, 2012 Jun 22. PMID 22723423, Free PMC Article
    5. Regulation of mitotic recombination between DNA repeats in centromeres. Zafar F, et al. Nucleic Acids Res, 2017 Nov 2. PMID 28977643, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. we confirm that Fml1 does indeed suppress IFSA, and show that this function depends on its catalytic activity and ability to interact with Mhf1-Mhf2 via its C-terminal domain.
      Title: The Fml1-MHF complex suppresses inter-fork strand annealing in fission yeast.
    2. Mutations that impair ATP hydrolysis of Fml1 block DNA unwinding without blocking DNA binding.
      Title: The ATPase activity of Fml1 is essential for its roles in homologous recombination and DNA repair.
    3. findings show that Fml1, the Fanconi anemia complementation group M (FANCM)-ortholog of Schizosaccharomyces pombe, directs the formation of non-crossovers (NCOs)during meiosis in competition with the Mus81-dependent pro-crossover (CO) pathway
      Title: The fission yeast FANCM ortholog directs non-crossover recombination during meiosis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables 3'-5' DNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to double-stranded DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables four-way junction DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables four-way junction DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables four-way junction helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables four-way junction helicase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA strand displacement IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in Okazaki fragment processing involved in mitotic DNA replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in double-strand break repair via synthesis-dependent strand annealing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in double-strand break repair via synthesis-dependent strand annealing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in interstrand cross-link repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in meiotic strand displacement involved in double-strand break repair via SDSA IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in reciprocal meiotic recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in recombinational interstrand cross-link repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in replication fork processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of FANCM-MHF complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in cytosol HDA PubMed 
    is_active_in nucleolus HDA PubMed 
    is_active_in nucleus HDA PubMed 
    is_active_in site of double-strand break IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ATP-dependent 3' to 5' DNA helicase

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      1470834..1476275
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001018780.4 → NP_593348.2  ATP-dependent 3' to 5' DNA helicase [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_593348.2

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q9UT23
      Conserved Domains (4) summary
      COG1111
      Location:58 → 613
      MPH1; ERCC4-related helicase [Replication, recombination and repair]
      cd00046
      Location:87 → 230
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cd00079
      Location:412 → 544
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      cd12091
      Location:280 → 396
      FANCM_ID; Insert domain of FANCM and related proteins
    Nucleotide Protein
    Heading Accession and Version

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