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    COA3 Coa3p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853383, updated on 9-Dec-2024

    Summary

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    Official Symbol
    COA3
    Official Full Name
    Coa3p
    Primary source
    SGD:S000007611
    Locus tag
    YJL062W-A
    See related
    AllianceGenome:SGD:S000007611; FungiDB:YJL062W-A; VEuPathDB:YJL062W-A
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    COX25; RRG10
    Summary
    Involved in mitochondrial cytochrome c oxidase assembly and negative regulation of mitochondrial translation. Located in mitochondrial inner membrane. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See COA3 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (316723..316980)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene Dls1p Neighboring gene mitochondrial 54S ribosomal protein YmL8 Neighboring gene mannose-ethanolamine phosphotransferase LAS21 Neighboring gene linker nucleoporin NUP82

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mimicking a SURF1 allele reveals uncoupling of cytochrome c oxidase assembly from translational regulation in yeast. Reinhold R, et al. Hum Mol Genet, 2011 Jun 15. PMID 21470975
    2. Crosstalk between cellular compartments protects against proteotoxicity and extends lifespan. Perić M, et al. Sci Rep, 2016 Jun 27. PMID 27346163, Free PMC Article
    3. Stabilization of Cox1p intermediates by the Cox14p-Coa3p complex. McStay GP, et al. FEBS Lett, 2013 Apr 2. PMID 23434581, Free PMC Article
    4. Cox25 teams up with Mss51, Ssc1, and Cox14 to regulate mitochondrial cytochrome c oxidase subunit 1 expression and assembly in Saccharomyces cerevisiae. Fontanesi F, et al. J Biol Chem, 2011 Jan 7. PMID 21068384, Free PMC Article
    5. The Cox1 C-terminal domain is a central regulator of cytochrome c oxidase biogenesis in yeast mitochondria. García-Villegas R, et al. J Biol Chem, 2017 Jun 30. PMID 28490636, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial cytochrome c oxidase assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial cytochrome c oxidase assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial cytochrome c oxidase assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of mitochondrial translation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Coa3p
    NP_076894.3
    • Mitochondrial protein required for cytochrome c oxidase assembly; also involved in translational regulation of Cox1p and prevention of Cox1p aggregation before assembly; located in the mitochondrial inner membrane

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      316723..316980
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184477.3 → NP_076894.3  TPA: Coa3p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_076894.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A6ZPQ9, B3LQ47, C7GR49, C8ZBF1, D6VWB9, Q3E7B2
      UniProtKB/TrEMBL
      G2WGV3, N1P346
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3E7B2.1

    Gene LinkOut

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