CKA1 casein kinase 2 catalytic subunit CKA1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: CKA1
Official Full Name: casein kinase 2 catalytic subunit CKA1
Primary source: SGD:S000001297
Locus tag: YIL035C
See related: AllianceGenome:SGD:S000001297; FungiDB:YIL035C; VEuPathDB:YIL035C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables protein serine/threonine kinase activity. Involved in DNA damage response; donor selection; and regulation of DNA-templated transcription. Part of UTP-C complex and protein kinase CK2 complex. Orthologous to human CSNK2A1 (casein kinase 2 alpha 1); CSNK2A2 (casein kinase 2 alpha 2); and CSNK2A3 (casein kinase 2 alpha 3). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See CKA1 in Genome Data Viewer

Location:: chromosome: IX

Exon count:: 1

Sequence:: Chromosome: IX; NC_001141.2 (287790..288908, complement)

Chromosome IX - NC_001141.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001141.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The role of CK2-dependent phosphorylation of Ifh1 and Crf1 in transcriptional regulation of ribosomal protein genes in Saccharomyces cerevisiae has been described.
Title: Role of CK2-dependent phosphorylation of Ifh1 and Crf1 in transcriptional regulation of ribosomal protein genes in Saccharomyces cerevisiae.
The authors provide strong evidence that Cka1p regulates Ycf1p function via phosphorylation of Ser251.
Title: Suppression of Ycf1p function by Cka1p-dependent phosphorylation is attenuated in response to salt stress.
protein kinase CK2 phosphorylates Ser(361) on Sgt1, and this phosphorylation inhibits Sgt1 dimerization
Title: Sgt1 dimerization is negatively regulated by protein kinase CK2-mediated phosphorylation at Ser361.
Studies in yeast and in human cells demonstrate that the different forms of CK2 interact with a large number of cellular proteins.
Title: The emerging CK2 interactome: insights into the regulation and functions of CK2.
Cka1p may regulate Ycf1p function through phosphorylation of Ser-251 either directly or indirectly.
Title: Negative regulation of the yeast ABC transporter Ycf1p by phosphorylation within its N-terminal extension.
Yeast transcription elongation factor Elf1 has been identified as a new substrate for protein kinase CK2 and coimmunoprecipitation shows that Elf1 interacts with catalytic (alpha and alpha') as well as regulatory (beta and beta') subunits of CK2.
Title: Yeast elf1 factor is phosphorylated and interacts with protein kinase CK2.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables 3-phosphoinositide-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables Rho-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS121 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AT120 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS139 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS14 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS36 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S28 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S57 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T11 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T3 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T45 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T6 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H4S1 kinase activity	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	HDA more info	PubMed
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables ribosomal protein S6 kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA damage response	IBA Inferred from Biological aspect of Ancestor more info
involved_in DNA damage response	IDA Inferred from Direct Assay more info	PubMed
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in donor selection	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase I	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of transcription by RNA polymerase III	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of UTP-C complex	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
part_of protein kinase CK2 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of protein kinase CK2 complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: casein kinase 2 catalytic subunit CKA1

NP_012229.1

EC 2.7.11.1

Alpha catalytic subunit of casein kinase 2 (CK2); a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases; regulates Fkh1p-mediated donor preference during mating-type switching

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001141.2 Reference assembly

Range

287790..288908 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001179385.1 → NP_012229.1 TPA: casein kinase 2 catalytic subunit CKA1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_012229.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VVP7, P15790

UniProtKB/TrEMBL

A6ZVN4, B3LTP1, B5VKR1, C7GVW3, C8ZAL1, G2WGB1, N1P271

Conserved Domains (1) summary

cd14132
Location:21 → 363

STKc_CK2_alpha; Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2