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    ndc80 protein Ndc80 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2540097, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ndc80
    Official Full Name
    protein Ndc80
    Primary source
    PomBase:SPBC11C11.03
    Locus tag
    SPOM_SPBC11C11.03
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    ndc10; tid3
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    Genomic context

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    See ndc80 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    3
    Sequence:
    Chromosome: II; NC_003423.3 (3350827..3352972)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene F-BAR domain protein Imp2 Neighboring gene tRNA-Ser Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene tubulin-specific chaperone cofactor D Alp1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The hairpin region of Ndc80 is important for the kinetochore recruitment of Mph1/MPS1 in fission yeast. Chmielewska AE, et al. Cell Cycle, 2016. PMID 26900649, Free PMC Article
    2. Ndc80 internal loop interacts with Dis1/TOG to ensure proper kinetochore-spindle attachment in fission yeast. Hsu KS, et al. Curr Biol, 2011 Feb 8. PMID 21256022, Free PMC Article
    3. The domain structure of centromeres is conserved from fission yeast to humans. Kniola B, et al. Mol Biol Cell, 2001 Sep. PMID 11553715, Free PMC Article
    4. The internal loop of fission yeast Ndc80 binds Alp7/TACC-Alp14/TOG and ensures proper chromosome attachment. Tang NH, et al. Mol Biol Cell, 2013 Apr. PMID 23427262, Free PMC Article
    5. Purification and characterisation of the fission yeast Ndc80 complex. Matsuo Y, et al. Protein Expr Purif, 2017 Jul. PMID 28502666, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ccp1-Ndc80 switch at the N terminus of CENP-T regulates kinetochore assembly.
      Title: Ccp1-Ndc80 switch at the N terminus of CENP-T regulates kinetochore assembly.
    2. Ndc80 comprises two microtubule-interacting interfaces: the N-terminal region directly binds the microtubule lattice, while the internal loop interacts with the plus end of microtubules via Dis1/TOG.
      Title: Ndc80 internal loop interacts with Dis1/TOG to ensure proper kinetochore-spindle attachment in fission yeast.
    3. Purification and characterization of the fission yeast Ndc80 complex has been described.
      Title: Purification and characterisation of the fission yeast Ndc80 complex.
    4. The Ndc80 hairpin region might act as a platform for the kinetochore recruitment of Mph1.
      Title: The hairpin region of Ndc80 is important for the kinetochore recruitment of Mph1/MPS1 in fission yeast.
    5. An Ndc80 loop plays sequential roles in spindle-kinetochore attachment by connecting the Ndc80 complex to Dis1/TOG and Alp7/TACC-Alp14/TOG.
      Title: The internal loop of fission yeast Ndc80 binds Alp7/TACC-Alp14/TOG and ensures proper chromosome attachment.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables kinetochore adaptor activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables kinetochore adaptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    contributes_to microtubule binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in attachment of mitotic spindle microtubules to kinetochore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in attachment of mitotic spindle microtubules to kinetochore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in attachment of mitotic spindle microtubules to kinetochore IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiotic centromere clustering IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic sister chromatid biorientation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in spindle attachment to meiosis I kinetochore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Ndc80 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Ndc80 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in chromosome, centromeric region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in condensed chromosome, centromeric region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in kinetochore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IC
    Inferred by Curator
    more info
    		  
    part_of outer kinetochore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein Ndc80

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      3350827..3352972
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001022313.3 → NP_596392.1  protein Ndc80 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_596392.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q10198
      Conserved Domains (3) summary
      COG5185
      Location:1 → 624
      HEC1; Protein involved in chromosome segregation, interacts with SMC proteins [Cell cycle control, cell division, chromosome partitioning]
      pfam03801
      Location:73 → 220
      Ndc80_HEC; HEC/Ndc80p family
      cl20817
      Location:267 → 371
      GBP_C; Guanylate-binding protein, C-terminal domain
    Nucleotide Protein
    Heading Accession and Version

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