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    nse2 Smc5-6 complex non-SMC SUMO ligase subunit Nse2 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2542312, updated on 18-Sep-2024

    Summary

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    Official Symbol
    nse2
    Official Full Name
    Smc5-6 complex non-SMC SUMO ligase subunit Nse2
    Primary source
    PomBase:SPAC16A10.06c
    Locus tag
    SPOM_SPAC16A10.06C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See nse2 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    3
    Sequence:
    Chromosome: I; NC_003424.3 (3089494..3090728, complement)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene Rho family GTPase Rho4 Neighboring gene ncRNA Neighboring gene DASH complex subunit Dad1 Neighboring gene ncRNA Neighboring gene telomere length regulator Neighboring gene ncRNA Neighboring gene protein mug74

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Nse2, a component of the Smc5-6 complex, is a SUMO ligase required for the response to DNA damage. Andrews EA, et al. Mol Cell Biol, 2005 Jan. PMID 15601841, Free PMC Article
    2. Slx8 removes Pli1-dependent protein-SUMO conjugates including SUMOylated topoisomerase I to promote genome stability. Steinacher R, et al. PLoS One, 2013. PMID 23936535, Free PMC Article
    3. Novel essential DNA repair proteins Nse1 and Nse2 are subunits of the fission yeast Smc5-Smc6 complex. McDonald WH, et al. J Biol Chem, 2003 Nov 14. PMID 12966087
    4. The SAGA histone acetyltransferase module targets SMC5/6 to specific genes. Mahrik L, et al. Epigenetics Chromatin, 2023 Feb 16. PMID 36793083, Free PMC Article
    5. Smc5-Smc6-dependent removal of cohesin from mitotic chromosomes. Outwin EA, et al. Mol Cell Biol, 2009 Aug. PMID 19528228, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. role in protecting genome stability against spontaneous Top1-mediated DNA damage
      Title: SUMO-targeted ubiquitin ligase, Rad60, and Nse2 SUMO ligase suppress spontaneous Top1-mediated DNA damage and genome instability.
    2. Nse1, Nse2, and Nse3 are crucial for meiosis. They also play an important role in mitigating the genome destabilizing effects of replication fork stalling. [Nse2]
      Title: Nse1, Nse2, and a novel subunit of the Smc5-Smc6 complex, Nse3, play a crucial role in meiosis.
    3. Nse1 and Nse2 are non-SMC subunits of the Smc5-6 DNA repair complex. They both interact with Smc5. Nse1 and Nse2 function together with Rhp51 in the homologous recombination repair of DNA double-strand breaks. They are essential proteins. [Nse2]
      Title: Novel essential DNA repair proteins Nse1 and Nse2 are subunits of the fission yeast Smc5-Smc6 complex.
    4. Nse2-dependent sumoylation activity has a role in DNA damage responses but not in the essential function of the Smc5-6 complex. [Nse2]
      Title: Nse2, a component of the Smc5-6 complex, is a SUMO ligase required for the response to DNA damage.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables SUMO ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables SUMO ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in double-strand break repair via homologous recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in double-strand break repair via homologous recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein sumoylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein sumoylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Smc5-Smc6 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Smc5-Smc6 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol HDA PubMed 
    is_active_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Smc5-6 complex non-SMC SUMO ligase subunit Nse2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      3089494..3090728 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001356098.2 → NP_001343015.1  Smc5-6 complex non-SMC SUMO ligase subunit Nse2 [Schizosaccharomyces pombe]

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q4PIR3
      Conserved Domains (2) summary
      cd16651
      Location:179 → 219
      SPL-RING_NSE2; SPL-RING finger [structural motif]
      cl17238
      Location:4 → 250
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
    Nucleotide Protein
    Heading Accession and Version

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