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    med20 mediator complex subunit Med20 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2542421, updated on 18-Sep-2024

    Summary

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    Official Symbol
    med20
    Official Full Name
    mediator complex subunit Med20
    Primary source
    PomBase:SPAC17G8.05
    Locus tag
    SPOM_SPAC17G8.05
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See med20 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    3
    Sequence:
    Chromosome: I; NC_003424.3 (2350193..2351244)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ARP2/3 actin-organizing complex subunit Arc5 Neighboring gene ncRNA Neighboring gene dihydroxy-acid dehydratase Neighboring gene ncRNA Neighboring gene NuA4 and Swr1 complex YEATS family subunit Yaf9

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Loss of the Mediator subunit Med20 affects transcription of tRNA and other non-coding RNA genes in fission yeast. Carlsten JO, et al. Biochim Biophys Acta, 2016 Feb. PMID 26608234
    2. Structure of the Mediator head module. Larivière L, et al. Nature, 2012 Dec 20. PMID 23123849
    3. Two conserved modules of Schizosaccharomyces pombe Mediator regulate distinct cellular pathways. Linder T, et al. Nucleic Acids Res, 2008 May. PMID 18310102, Free PMC Article
    4. Core Mediator structure at 3.4 Å extends model of transcription initiation complex. Nozawa K, et al. Nature, 2017 May 11. PMID 28467824
    5. Conservation and rewiring of functional modules revealed by an epistasis map in fission yeast. Roguev A, et al. Science, 2008 Oct 17. PMID 18818364, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. loss of Med20 leads to an accumulation of aberrant, readthrough tRNA transcripts. These transcripts are polyadenylated and targeted for degradation by the exosome.
      Title: Loss of the Mediator subunit Med20 affects transcription of tRNA and other non-coding RNA genes in fission yeast.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of transcription initiation by RNA polymerase II EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of mediator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mediator complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    mediator complex subunit Med20

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      2350193..2351244
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001019159.3 → NP_593728.2  mediator complex subunit Med20 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_593728.2

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q10317
      Conserved Domains (1) summary
      pfam08612
      Location:1 → 180
      Med20; TATA-binding related factor (TRF) of subunit 20 of Mediator complex
    Nucleotide Protein
    Heading Accession and Version

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