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    tea4 tip elongation aberrant protein Tea4 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2539642, updated on 14-Nov-2024

    Summary

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    Official Symbol
    tea4
    Official Full Name
    tip elongation aberrant protein Tea4
    Primary source
    PomBase:SPBC1706.01
    Locus tag
    SPOM_SPBC1706.01
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    wsh3
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    Genomic context

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    See tea4 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_003423.3 (588359..591434)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene L-pipecolate oxidase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ubiquitination of CLIP-170 family protein restrains polarized growth upon DNA replication stress. Wang X, et al. Nat Commun, 2022 Sep 22. PMID 36138017, Free PMC Article
    2. Wsh3/Tea4 is a novel cell-end factor essential for bipolar distribution of Tea1 and protects cell polarity under environmental stress in S. pombe. Tatebe H, et al. Curr Biol, 2005 Jun 7. PMID 15936270
    3. Schizosaccharomyces pombe protein phosphatase 1 in mitosis, endocytosis and a partnership with Wsh3/Tea4 to control polarised growth. Alvarez-Tabarés I, et al. J Cell Sci, 2007 Oct 15. PMID 17895368
    4. Casein kinase 1γ acts as a molecular switch for cell polarization through phosphorylation of the polarity factor Tea1 in fission yeast. Koyano T, et al. Genes Cells, 2015 Dec. PMID 26525038, Free PMC Article
    5. PKA antagonizes CLASP-dependent microtubule stabilization to re-localize Pom1 and buffer cell size upon glucose limitation. Kelkar M, et al. Nat Commun, 2015 Oct 7. PMID 26443240, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Study proposes that Cki3 monitors the timing of growth polarity transition from monopolar to bipolar during G2 phase onset through Tea1 phosphorylation by regulating the interaction between Tea1 and Tea4.
      Title: Casein kinase 1γ acts as a molecular switch for cell polarization through phosphorylation of the polarity factor Tea1 in fission yeast.
    2. Tea4-PP1 landmark promotes local Cdc42 activation and growth both through Cdc42 GEF recruitment and by creating a local trough in a Cdc42 GAP.
      Title: The Tea4-PP1 landmark promotes local growth by dual Cdc42 GEF recruitment and GAP exclusion.
    3. study reports distribution of the 2 PP1 isoforms (dis2 & Sds21)in fission yeast to new subcellular locations & demonstrates that recruitment of Dis2 to cell tips by Wsh3/Tea4 is important for the regulation of the microtubule-mediated polarised tip growth
      Title: Schizosaccharomyces pombe protein phosphatase 1 in mitosis, endocytosis and a partnership with Wsh3/Tea4 to control polarised growth.
    4. Tea4/Wsh3, an essential component of the Tea1 cell-end complex, is required for bipolar distribution of Tea1 and contributes to the maintenance of cell polarity under stress conditions. [tea4]
      Title: Wsh3/Tea4 is a novel cell-end factor essential for bipolar distribution of Tea1 and protects cell polarity under environmental stress in S. pombe.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables cytoskeletal anchor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in establishment of bipolar cell polarity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in establishment of cell polarity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in establishment or maintenance of actin cytoskeleton polarity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in establishment or maintenance of actin cytoskeleton polarity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in establishment or maintenance of actin cytoskeleton polarity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in establishment or maintenance of bipolar cell polarity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in establishment or maintenance of bipolar cell polarity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in maintenance of protein location in cell cortex of cell tip IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell cortex of cell tip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cell division site IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cell tip IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cell tip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in lateral cell cortex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in microtubule cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in microtubule plus-end IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in non-growing cell tip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in old growing cell tip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tip elongation aberrant protein Tea4

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      588359..591434
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001021146.3 → NP_595240.2  tip elongation aberrant protein Tea4 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_595240.2

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O60132
      Conserved Domains (1) summary
      smart00326
      Location:131 → 187
      SH3; Src homology 3 domains
    Nucleotide Protein
    Heading Accession and Version

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