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    dhc1 dynein heavy chain, minus-end directed microtubule motor Dhc1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 3361400, updated on 18-Sep-2024

    Summary

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    Official Symbol
    dhc1
    Official Full Name
    dynein heavy chain, minus-end directed microtubule motor Dhc1
    Primary source
    PomBase:SPAC1093.06c
    Locus tag
    SPOM_SPAC1093.06C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    SPAC30C2.01c
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    Genomic context

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    See dhc1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    1
    Sequence:
    Chromosome: I; NC_003424.3 (4622166..4634756, complement)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ATP-dependent RNA helicase Hca4 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene deoxyhypusine hydroxylase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A cytoplasmic dynein heavy chain is required for oscillatory nuclear movement of meiotic prophase and efficient meiotic recombination in fission yeast. Yamamoto A, et al. J Cell Biol, 1999 Jun 14. PMID 10366596, Free PMC Article
    2. Self-organization of dynein motors generates meiotic nuclear oscillations. Vogel SK, et al. PLoS Biol, 2009 Apr 21. PMID 19385717, Free PMC Article
    3. Dynein participates in chromosome segregation in fission yeast. Courtheoux T, et al. Biol Cell, 2007 Nov. PMID 17561805
    4. Microtubule minus end motors kinesin-14 and dynein drive nuclear congression in parallel pathways. Scheffler K, et al. J Cell Biol, 2015 Apr 13. PMID 25869666, Free PMC Article
    5. Telomeres and centromeres have interchangeable roles in promoting meiotic spindle formation. Fennell A, et al. J Cell Biol, 2015 Feb 16. PMID 25688135, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Force by minus-end motors Dhc1 and Klp2 collapses the S. pombe spindle after laser ablation.
      Title: Force by minus-end motors Dhc1 and Klp2 collapses the S. pombe spindle after laser ablation.
    2. Klp2-dependent nuclear congression proceeds at constant speed, whereas dynein accumulation results in an increase of nuclear velocity over time.
      Title: Microtubule minus end motors kinesin-14 and dynein drive nuclear congression in parallel pathways.
    3. role for dynein in the control of chromosome segregation in fission yeast, most probably operating during the process of bi-orientation during early mitosis.
      Title: Dynein participates in chromosome segregation in fission yeast.
    4. Dhc1 is required for chromosome segregation in both the presence and the absence of recombination, and Dlc1 preferentially affects the segregation of achiasmate chromosomes
      Title: Dynein promotes achiasmate segregation in Schizosaccharomyces pombe.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables ATP binding ISM
    Inferred from Sequence Model
    more info
    		  
    enables ATP hydrolysis activity IC
    Inferred by Curator
    more info
    		  
    enables dynein intermediate chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dynein light intermediate chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables minus-end-directed microtubule motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables minus-end-directed microtubule motor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in attachment of mitotic spindle microtubules to kinetochore IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cytoplasmic microtubule organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in dynein-driven meiotic oscillatory nuclear movement IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in dynein-driven meiotic oscillatory nuclear movement IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in homologous chromosome pairing at meiosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in karyogamy involved in conjugation with cellular fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic spindle organization EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in mitotic spindle organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear migration involved in conjugation with cellular fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cell cortex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cell cortex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cortical microtubule cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of cytoplasmic dynein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytoplasmic dynein complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasmic microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in meiotic spindle astral microtubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in meiotic spindle pole body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in spindle pole body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    dynein heavy chain, minus-end directed microtubule motor Dhc1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      4622166..4634756 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001356171.2 → NP_001342921.1  dynein heavy chain, minus-end directed microtubule motor Dhc1 [Schizosaccharomyces pombe]

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O13290, Q9P6L0, Q9UTP8
      Conserved Domains (3) summary
      COG5245
      Location:1605 → 4196
      DYN1; Dynein, heavy chain [Cytoskeleton]
      pfam08385
      Location:251 → 816
      DHC_N1; Dynein heavy chain, N-terminal region 1
      pfam08393
      Location:1322 → 1718
      DHC_N2; Dynein heavy chain, N-terminal region 2
    Nucleotide Protein
    Heading Accession and Version

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