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    CBS2 Cbs2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851778, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CBS2
    Official Full Name
    Cbs2p
    Primary source
    SGD:S000002605
    Locus tag
    YDR197W
    See related
    AllianceGenome:SGD:S000002605; FungiDB:YDR197W; VEuPathDB:YDR197W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    CBP7
    Summary
    Enables translation regulator activity. Involved in positive regulation of mitochondrial translation. Located in mitochondrial ribosome. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See CBS2 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (851228..852397)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene RNA-processing protein REF2 Neighboring gene putative dephospho-CoA kinase Neighboring gene protein-lysine N-methyltransferase Neighboring gene Vps64p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. CBP7 codes for a co-factor required in conjunction with a mitochondrial maturase for splicing of its cognate intervening sequence. Muroff I, et al. EMBO J, 1990 Sep. PMID 1697264, Free PMC Article
    2. Identification of CBS2 as a mitochondrial protein in Saccharomyces cerevisiae. Michaelis U, et al. Mol Gen Genet, 1990 Sep. PMID 2270079
    3. Expression, purification, crystallization and preliminary X-ray crystallographic studies of a mitochondrial membrane-associated protein Cbs2 from Saccharomyces cerevisiae. Wu D, et al. PeerJ, 2021. PMID 33643713, Free PMC Article
    4. Saccharomyces cerevisiae translational activator Cbs2p is associated with mitochondrial ribosomes. Krause-Buchholz U, et al. Curr Genet, 2004 Jul. PMID 15127226
    5. Yeast nuclear gene CBS2, required for translational activation of cytochrome b, encodes a basic protein of 45 kDa. Michaelis U, et al. Mol Gen Genet, 1988 Oct. PMID 3070350

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables 2-dehydropantoate 2-reductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables NADP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation regulator activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of mitochondrial translation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial ribosome IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Cbs2p
    NP_010483.1
    • Mitochondrial translational activator of the COB mRNA; interacts with translating ribosomes, acts on the COB mRNA 5'-untranslated leader

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      851228..852397
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180505.1 → NP_010483.1  TPA: Cbs2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010483.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VSI0, P14905
      UniProtKB/TrEMBL
      A6ZYF6, B3LG86, C7GN00, C8Z5B2, G2WAU6, N1PAF3
      Conserved Domains (1) summary
      COG1893
      Location:6 → 383
      PanE; Ketopantoate reductase [Coenzyme transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P14905.1

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