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    SED4 GTPase-activating protein SED4 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850431, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SED4
    Official Full Name
    GTPase-activating protein SED4
    Primary source
    SGD:S000000663
    Locus tag
    YCR067C
    See related
    AllianceGenome:SGD:S000000663; FungiDB:YCR067C; VEuPathDB:YCR067C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables GTPase activator activity. Involved in regulation of COPII vesicle coating. Located in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SED4 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    1
    Sequence:
    Chromosome: III; NC_001135.5 (233125..236322, complement)

    Chromosome III - NC_001135.5Genomic Context describing neighboring genes Neighboring gene Hcm1p Neighboring gene E3 ubiquitin-protein ligase RAD18 Neighboring gene triglyceride lipase ATG15 Neighboring gene peptidylprolyl isomerase family protein CPR4

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001135.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Sec16 and Sed4 interdependently function as interaction and localization partners at ER exit sites. Yorimitsu T, et al. J Cell Sci, 2023 May 1. PMID 37158682, Free PMC Article
    2. Sed4p stimulates Sar1p GTP hydrolysis and promotes limited coat disassembly. Kodera C, et al. Traffic, 2011 May. PMID 21291503
    3. Sec24p and Sec16p cooperate to regulate the GTP cycle of the COPII coat. Kung LF, et al. EMBO J, 2012 Feb 15. PMID 22157747, Free PMC Article
    4. Combinatorial multivalent interactions drive cooperative assembly of the COPII coat. Stancheva VG, et al. J Cell Biol, 2020 Nov 2. PMID 32997735, Free PMC Article
    5. Genes that allow yeast cells to grow in the absence of the HDEL receptor. Hardwick KG, et al. EMBO J, 1992 Nov. PMID 1327759, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables GTPase activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of COPII vesicle coating IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of COPII vesicle coating IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm HDA PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    GTPase-activating protein SED4
    NP_009993.1
    • Integral ER membrane protein that stimulates Sar1p GTPase activity; involved in COPII vesicle budding through disassociation of coat proteins from membranes onto liposomes; binds Sec16p; SED4 has a paralog, SEC12, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001135.5 Reference assembly

      Range
      233125..236322 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178778.1 → NP_009993.1  TPA: GTPase-activating protein SED4 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009993.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VR70, P25365
      UniProtKB/TrEMBL
      B3LUC5, C7GUX8
      Conserved Domains (3) summary
      sd00039
      Location:172 → 209
      7WD40; WD40 repeat [structural motif]
      NF033849
      Location:727 → 1009
      ser_rich_anae_1; serine-rich protein
      cl29593
      Location:171 → 330
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P25365.1

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