rrp6 exosome 3'-5' exoribonuclease subunit Rrp6 [Schizosaccharomyces pombe (fission yeast)] - Gene

Summary

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Official Symbol: rrp6
Official Full Name: exosome 3'-5' exoribonuclease subunit Rrp6
Primary source: PomBase:SPAC1F3.01
Locus tag: SPOM_SPAC1F3.01
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Schizosaccharomyces pombe (strain: 972h-)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as: SPAC3H8.11
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Genomic context

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See rrp6 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 2

Sequence:: Chromosome: I; NC_003424.3 (610848..613338)

Chromosome I - NC_003424.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Rrp6 may act as a structural adapter to target specific RNAs to the exosome by interacting with sequence-specific RNA-binding proteins.
Title: Relative contributions of the structural and catalytic roles of Rrp6 in exosomal degradation of individual mRNAs.
Pab2 and the nuclear exosome subunit, Rrp6 are the main factors involved in this polyadenylation-dependent pre-mRNA degradation pathway
Title: A Pre-mRNA degradation pathway that selectively targets intron-containing genes requires the nuclear poly(A)-binding protein.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by PomBase

Function	Evidence Code	Pubs
enables 3'-5'-RNA exonuclease activity	IBA Inferred from Biological aspect of Ancestor more info
enables RNA exonuclease activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables single-stranded RNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in TRAMP-dependent tRNA surveillance pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IBA Inferred from Biological aspect of Ancestor more info
involved_in histone mRNA catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in nonfunctional rRNA decay	ISO Inferred from Sequence Orthology more info
involved_in nuclear polyadenylation-dependent CUT catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in nuclear polyadenylation-dependent CUT catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nuclear polyadenylation-dependent antisense transcript catabolic process	EXP Inferred from Experiment more info	PubMed
involved_in nuclear polyadenylation-dependent antisense transcript catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in nuclear polyadenylation-dependent mRNA catabolic process	ISO Inferred from Sequence Orthology more info
involved_in nuclear polyadenylation-dependent rRNA catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in nuclear polyadenylation-dependent snRNA catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in nuclear polyadenylation-dependent snoRNA catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in nuclear-transcribed mRNA catabolic process, meiosis-specific transcripts	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in poly(A)-dependent snoRNA 3'-end processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulatory ncRNA-mediated gene silencing	EXP Inferred from Experiment more info	PubMed
involved_in siRNA catabolic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in chromatin	IDA Inferred from Direct Assay more info	PubMed
is_active_in cleavage body	IDA Inferred from Direct Assay more info	PubMed
part_of exosome (RNase complex)	IDA Inferred from Direct Assay more info	PubMed
is_active_in heterochromatin island	IDA Inferred from Direct Assay more info	PubMed
part_of nuclear exosome (RNase complex)	EXP Inferred from Experiment more info	PubMed
part_of nuclear exosome (RNase complex)	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nuclear exosome focus	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleolar peripheral inclusion body	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleolus	HDA more info	PubMed
is_active_in nucleolus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleolus	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	HDA more info	PubMed

General protein information

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Preferred Names: exosome 3'-5' exoribonuclease subunit Rrp6

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003424.3 Reference assembly

Range

610848..613338

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001018403.3 → NP_593004.2 exosome 3'-5' exoribonuclease subunit Rrp6 [Schizosaccharomyces pombe]

See identical proteins and their annotated locations for NP_593004.2

Status: PROVISIONAL

UniProtKB/Swiss-Prot

Q10146

Conserved Domains (3) summary

cd06147
Location:214 → 405

Rrp6p_like_exo; DEDDy 3'-5' exonuclease domain of yeast Rrp6p, human polymyositis/scleroderma autoantigen 100kDa, and similar proteins

smart00341
Location:442 → 522

HRDC; Helicase and RNase D C-terminal

pfam08066
Location:14 → 98

PMC2NT; PMC2NT (NUC016) domain