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    mes1 protein Mes1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2541861, updated on 18-Sep-2024

    Summary

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    Official Symbol
    mes1
    Official Full Name
    protein Mes1
    Primary source
    PomBase:SPAC5D6.08c
    Locus tag
    SPOM_SPAC5D6.08C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See mes1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    2
    Sequence:
    Chromosome: I; NC_003424.3 (1498898..1500084)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene protein mug116 Neighboring gene ncRNA Neighboring gene acetate transmembrane transporter Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Fission yeast APC/C activators Slp1 and Fzr1 sequentially trigger two consecutive nuclear divisions during meiosis. Chikashige Y, et al. FEBS Lett, 2017 Apr. PMID 28245054
    2. Cuf2 boosts the transcription of APC/C activator Fzr1 to terminate the meiotic division cycle. Aoi Y, et al. EMBO Rep, 2013 Jun. PMID 23628763, Free PMC Article
    3. The RNA-binding protein Spo5 promotes meiosis II by regulating cyclin Cdc13 in fission yeast. Arata M, et al. Genes Cells, 2014 Mar. PMID 24506453
    4. A mutual inhibition between APC/C and its substrate Mes1 required for meiotic progression in fission yeast. Kimata Y, et al. Dev Cell, 2008 Mar. PMID 18331722
    5. Fission yeast Mes1p ensures the onset of meiosis II by blocking degradation of cyclin Cdc13p. Izawa D, et al. Nature, 2005 Mar 24. PMID 15791259

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mes1 interacts with two coactivators in a different way to control the activity of the APC/C required for the meiosis I/meiosis II transition.
      Title: Mes1 controls the meiosis I to meiosis II transition by distinctly regulating the anaphase-promoting complex/cyclosome coactivators Fzr1/Mfr1 and Slp1 in fission yeast.
    2. Mes1 is a substrate of the APC/C as well as an inhibitor, allowing autoregulation of the APC/C in meiosis.
      Title: A mutual inhibition between APC/C and its substrate Mes1 required for meiotic progression in fission yeast.
    3. Mes1p is a factor that suppresses the degradation of cyclin Cdc13p at anaphase I
      Title: Fission yeast Mes1p ensures the onset of meiosis II by blocking degradation of cyclin Cdc13p.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin ligase inhibitor activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables ubiquitin ligase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in meiosis I/meiosis II transition IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in metaphase/anaphase transition of meiosis I IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of metaphase/anaphase transition of meiotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol HDA PubMed 
    is_active_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    protein Mes1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      1498898..1500084
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001018793.3 → NP_593361.1  protein Mes1 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_593361.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P41005
    Nucleotide Protein
    Heading Accession and Version

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